Dec 7, 2023 · The Sepsis 6 is a rapid response protocol designed to streamline the assessment and management of sepsis. This evidence-based protocol consists of six key interventions that should be initiated within the first hour of sepsis recognition.

The Sepsis Six consists of three diagnostic and three therapeutic steps – all to be delivered within one hour of the initial diagnosis of sepsis: [citation needed] Titrate oxygen to a saturation target of 94%; Take blood cultures and consider source control; Administer empiric intravenous antibiotics; Measure serial serum lactates

Oct 4, 2023 · An overview of the recognition and management of sepsis, including sepsis screening tools and the sepsis six.

Mar 23, 2025 · The Sepsis Six, or rule of six for sepsis, is a vital tool for front-line healthcare workers in the early management of sepsis. The six-pronged approach focuses on key interventions that address the body’s systemic response to infection.

Definitions: Sepsis is a syndrome characterized by life-threatening organ dysfunction caused by a dysregulated host response to infection. 1 SEP3 clinically defined sepsis as acute organ dysfunction (e.g., ≥2 new SOFA points), plus evidence of infection 2.

The components of the sepsis 6 are: blood cultures, check full blood count and lactate, IV fluid challenge, IV antibiotics, monitor urine output and give oxygen. Patients with a lactate over 4 due to sepsis have a mortality of approximately 40% ( 5 ), therefore knowing the lactate helps to escalate appropriate patients early ( 6 ).

Jul 13, 2016 · It includes recommendations on recognition and early assessment, initial treatment, escalating care, finding and controlling the source of infection, early monitoring, information and support, and training and education. Last reviewed: 19 March 2024.