The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein …

Mar 30, 2025 · SEC63 (SEC63 Homolog, Protein Translocation Regulator) is a Protein Coding gene. Diseases associated with SEC63 include Polycystic Liver Disease 2 With Or Without …

Apr 28, 2017 · In this article, we review the current understanding of protein transport across the ER membrane as central function of Sec proteins and further focus on recent studies that gave …

May 9, 2004 · We found that mutations in SEC63, encoding a component of the protein translocation machinery in the ER, also cause this disease. These findings are suggestive of a …

Here we report that inactivation of SEC63 induces an unfolded protein response (UPR) pathway that is protective against cyst formation. Specifically, using murine genetic models, we …

Dec 10, 2024 · Clinical resource with information about SEC63, Polycystic liver disease 2, and available tests. There are links to practice guidelines and authoritative resources like …

Nov 25, 2021 · For the last three decades, it has been thought that ER protein targeting and translocation occur via two distinct pathways: signal recognition particle (SRP)-dependent co …

Jul 20, 2016 · SEC63 works in concert with the SEC61 translocon (see 609213) and BIP (HSPA5; 138120) to facilitate cotranslational translocation across the endoplasmic reticulum (ER) …

Collectively, the findings show that SEC63 function regulates IRE1α/XBP1 activation, SEC63 and XBP1 are required for GPS cleavage and maturation of PC1, and activation of XBP1 can …

Feb 8, 2025 · Enables protein transmembrane transporter activity. Involved in SRP-dependent cotranslational protein targeting to membrane; cytosol to endoplasmic reticulum transport; and …