Mar 8, 2022 · The results demonstrated a physical interaction among MVBs, Rab11a, and exocysts (Figure 5J). With the knockdown of Rab11a expression, the interactions between the MVBs marker CD63 and Sec10, Sec3, or Exo70 were significantly weakened (Figures 5K–5N).

Here, we identify Rab11a and Rab11b as regulators of Ca 2+ -induced lysosome exocytosis. Interestingly, Rab11-positive vesicles transiently interact with lysosomes at the cell periphery, indicating that this interaction is required for the last steps of lysosome exocytosis.

Sep 1, 2012 · Rab11 is known to associate primarily with perinuclear recycling endosomes and regulate recycling of endocytosed proteins. However, the recycling step in which Rab11 participates remains unknown.

Mar 6, 2021 · Here, we identify Rab11a and Rab11b as regulators of calcium-induced lysosome exocytosis. Interestingly, Rab11-positive vesicles transiently interact with lysosomes at the cell periphery,...

Jul 1, 2019 · The small GTPases Rab11a and 11b are key regulators of membrane transport, localised to the recycling endosomes and also early endosomes. The function of Rab11 within the recycling pathway has been well defined, however, the role of Rab11 at the early endosomes remains poorly characterised.

Jan 23, 2009 · Rab11A has a dynamic distribution throughout parasite development in red blood cells. Rab11A has been shown to be rhoptry-associated in T. gondii, which might indicate a role for this GTPase in regulating vesicular traffic to the rhoptries, and/or in release of rhoptry contents in the Apicomplexa.

Dec 1, 2021 · Rab11a, a small GTPase that is involved in MVB fusion, also interacted with the exocyst. These findings suggest that exocyst can regulate exosome biogenesis and participate …

Sep 14, 2018 · Here, we present the structure of Rab11 bound to the GEF SH3BP5, along with detailed characterization of Rab-GEF specificity. The structure of SH3BP5 shows a coiled-coil architecture that...

Mar 1, 2013 · Rab11-FIPs influence the distribution and movement of Rab11a-containing vesicles. As a second line of evidence for differential roles of the Rab11-FIPs in vesicle recycling, we examined how these effector proteins influenced and overlapped with Rab11a.

Jun 8, 2021 · Here, we identify Rab11a and Rab11b as regulators of Ca 2+ -induced lysosome exocytosis. Interestingly, Rab11-positive vesicles transiently interact with lysosomes at the cell periphery, indicating that this interaction is required for the last steps of lysosome exocytosis.