Succinate dehydrogenase (SDH) is part of both the citric acid cycle and respiratory electron transfer chain. Within the citric acid cycle, SDH oxidizes succinate to fumarate. SDH is …

Succinate dehydrogenase (SDH) or succinate-coenzyme Q reductase (SQR) or respiratory complex II is an enzyme complex, found in many bacterial cells and in the inner mitochondrial …

Succinate serves as an essential circulating metabolite within the tricarboxylic acid (TCA) cycle and functions as a substrate for succinate dehydrogenase (SDH), thereby contributing to …

SDH catalyzes one step of the TCA cycle, the oxidation of succinate to fumarate. Instead of reducing NAD + like all the other oxidative steps of the TCA cycle, the electrons are …

Oct 1, 2023 · SDH is the unique OXPHOS complex involved in the TCA cycle. By converting succinate to fumarate, SDH functions not only as an enzyme but also as a metabolic switch …

Sep 9, 2024 · Owing to the privileged position of SDH/CII, its dysfunction leads to TCA cycle arrest and altered respiration. This review aims to elucidate the widely documented profound …

Mitochondrial succinate dehydrogenase (SDH), also known as electron transport chain (ETC) Complex II, is the only enzyme complex engaged in both oxidative phosphorylation and the …

Jul 6, 2023 · Succinate dehydrogenase (SDH) is the mitochondrial enzyme converting succinate to fumarate in the tricarboxylic acid (TCA) cycle. SDH acts as a tumor suppressor with germline...

Apr 29, 2022 · Succinate dehydrogenase (SDH)/complex II consists of four subunits (SDHA to SDHD) that function in both the TCA cycle and the electron transportation chain (ETC). Its …

Aug 5, 2014 · Succinate dehydrogenase (SDH) links the TCA cycle to the electron transport chain, and mutations in this complex have been linked to cancers and neuromuscular …