Sclerostin is a protein that in humans is encoded by the SOST gene. [5] . It is a secreted glycoprotein with a C-terminal cysteine knot -like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists.

Sclerostin is a small protein expressed by the SOST gene in osteocytes, bone cells that respond to mechanical stress applied to the skeleton and appear to play an important role in the regulation of bone remodeling.

In this review, we highlight the current knowledge on the regulation of Sost/sclerotin expression and its mechanism (s) of action, discuss novel observations regarding its role in signaling pathways activated by hormones and mechanical stimuli in bone, and propose future research needed to understand the full potential of therapeutic ...

In this review, we highlight the current knowledge on the regulation of Sost/sclerotin expression and its mechanism (s) of action, discuss novel observations regarding its role in signaling pathways activated by hormones and mechanical stimuli in bone, and propose future research needed to understand the full potential of therapeutic interventio...

Sclerostin is a Wnt inhibitor, produced by osteocytes which inhibits osteoblast-induced bone formation (Moester et al., 2010). The production of sclerostin is upregulated by glucocorticoids, while intermittent parathyroid hormone (PTH) inhibits the production by osteocytes.

May 12, 2022 · Sclerostin is an important bone remodeling protein but may also play a role in cardiovascular disease. In preclinical models, sclerostin has been reported to protect against abdominal aortic aneurysm and atherosclerosis formation and prevent cardiac rupture.

Feb 22, 2022 · Sclerostin has been identified as an important regulator of bone homeostasis through inhibition of the canonical Wnt-signaling pathway, and it is involved in the pathogenesis of many different skeletal diseases.

Sclerostin is a glycoprotein involved in the regulation of bone metabolism, exclusively secreted by osteocytes. It affects the activity of bone morphogenetic proteins (BMPs) and is an inhibitor of the Wnt/β-catenin metabolic pathway in bone cells.

Jan 1, 2016 · Sclerostin, an inhibitor of the Wnt/β-catenin signalling pathway that regulates bone growth, has become an attractive therapeutic target for treating osteoporosis. In this review, we summarize the recent findings of sclerostin and its potential as an effective drug target for treating both osteoporosis and osteoporotic fractures. Previous

Apr 7, 2025 · Sclerosteosis is caused by SOST mutations and loss of functional sclerostin, a protein that suppresses osteogenesis by antagonising Wnt/β-catenin signalling.