SAV1 - Wikipedia
Protein salvador homolog 1 is a protein that in humans is encoded by the SAV1 gene. [5][6][7] WW domain -containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as …
SAV1 Gene - GeneCards | SAV1 Protein | SAV1 Antibody
Mar 30, 2025 · SAV1 (Salvador Family WW Domain Containing Protein 1) is a Protein Coding gene. Diseases associated with SAV1 include Microphthalmia, Syndromic 10 and Hepatocellular Clear Cell Carcinoma.
SAV1 salvador family WW domain containing protein 1 [ (human)]
Feb 8, 2025 · Authors report that SAV1, a Hippo signaling component, inhibits Akt, a function independent of its role in Hippo signaling. Binding to a proline-tyrosine motif in the Akt-PH domain, SAV1 suppresses Akt activation by blocking Akt's movement to plasma membrane.
Correction of the tumor suppressor Salvador homolog-1 ... - Nature
May 21, 2020 · Salvador homolog-1 (SAV1) is a tumor suppressor required for activation of the tumor-suppressive Hippo pathway and inhibition of tumorigenesis. SAV1 is defective in several cancer types.
SAV1, regulated by HERC4, inhibits the proliferation, migration, …
Jan 21, 2020 · Salvador 1 (SAV1) plays a key role in a variety of human carcinogenesis. This study investigated the role of SAV1 and HERC4 in hepatocellular carcinoma (HCC). SAV1 and HERC4 expressions in HCC tissues were examined using RT-qPCR assay.
SAV1 [Homo sapiens] - Protein - NCBI
SAV1 represses the development of human colorectal cancer by regulating the Akt-mTOR pathway in a YAP-dependent manner. Jiang J, Chang W, Fu Y, Gao Y, Zhao C, Zhang X, Zhang S. Cell Prolif. 2017 Aug; 50 (4).
SAV1, regulated by HERC4, inhibits the proliferation ... - PubMed
Salvador 1 (SAV1) plays a key role in a variety of human carcinogenesis. This study investigated the role of SAV1 and HERC4 in hepatocellular carcinoma (HCC). Methods: SAV1 and HERC4 …
Protein salvador homolog 1 acts as a tumor suppressor and is …
Our results revealed that SAV1 suppressed expression promoted PDAC invasion and migration, and repressed pancreatic cancer cells apoptosis. Moreover, SAV1 was silenced by hypermethylation. Thus, SAV1 worked as a cancer suppressor and it might be considered as a target for pancreatic cancer therapy.
SAV1, regulated by microRNA-21, suppresses tumor growth in
Our results revealed that SAV1 was downregulated in CRC tissues compared with the adjacent noncancerous tissues. Furthermore, SAV1 overexpression inhibited proliferation and promoted apoptosis in SW480 and HCT116 cells, whereas knockdown of SAV1 exerted the opposite effect.
Sav1 Loss Induces Senescence and Stat3 Activation Coinciding …
Collectively, these results support a role for Sav1 loss in regulating interstitial fibrosis and suggest that events associated with senescence and Stat3 activation are the mechanisms underlying renal fibrosis induced by Sav1 loss.