May 28, 2020 · Currently, detecting SARS-CoV-2 RNAs is a standard approach for COVID-19 diagnosis. However, there is an urgent need for reliable and rapid serological diagnostic methods to screen...

In this study, we found that level of IgM was increased during the first week after SARS‐CoV‐2 infection and reached its peak level after 2 weeks, while IgG reached its peak in 3 weeks, which was maintained at a high level even over 48 days.

Aug 18, 2020 · A recent study demonstrated enrichment of spike-specific IgM and IgA1 Abs and spike-specific phagocytic and antibody-dependent complement deposition (ADCD) activity in plasma of individuals who recovered from SARS-CoV-2 infection, while nucleocapsid-specific IgM and IgA2 responses and nucleocapsid-specific ADCD activity were features enriched ...

Apr 29, 2020 · Within 19 days after symptom onset, 100% of patients tested positive for antiviral immunoglobulin-G (IgG). Seroconversion for IgG and IgM occurred simultaneously or sequentially. Both IgG and...

Jun 13, 2021 · Although each of the anti-SARS-CoV-2 mAbs was able to neutralize the spike-coated lentiviruses, IgM and IgA neutralized the viral particles at 225-fold and 125-fold lower concentrations, respectively, than that of IgG.

The serological testing of anti‐SARS‐CoV‐2 immunoglobulin G (IgG) and/or IgM is widely used in the diagnosis of COVID‐19. However, its diagnostic efficacy remains unclear.

May 19, 2022 · Respiratory tract infection with SARS-CoV-2 results in varying immunopathology underlying COVID-19. We examine cellular, humoral and cytokine responses covering 382 immune components in...

May 13, 2020 · We investigated IgM and IgG responses against SARS-CoV-2 nucleocapsid (N) and spike (S) protein after symptom onset in the intensive care unit (ICU) and non-ICU patients. 130 blood samples from 38 COVID-19 patients were collected. The levels of IgM and IgG specific to N and S protein were detected by ELISA.

Apr 13, 2022 · IgG levels against SARS‐CoV‐2 increased after symptom onset in all patients with COVID‐19 but levels of IgM and IgA against N and S1 exhibited different increasing trends among patients (Figure 1A–F). For example, in Patient 5, IgM and IgG levels were low but IgA levels were high on Day 11.

Jul 1, 2023 · Typically, the level of IgM antibody lasts for a relatively short period after SARS-CoV-2 infection, which is regarded as a good and promising diagnostic biomarker for early SARS-CoV-2 infection, and it can provide a reliable reference basis for early clinical intervention.