Sin3A-associated protein, 30kDa, also known as SAP30, is a protein which in humans is encoded by the SAP30 gene. [5] Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes.

Mar 30, 2025 · SAP30 (Sin3A Associated Protein 30) is a Protein Coding gene. Diseases associated with SAP30 include Phlebotomus Fever and Retinoblastoma . Among its related pathways are RNA Polymerase I Promoter Opening and Infectious disease .

Here, we identify SAP30 as a novel component of the human histone deacetylase complex that includes Sin3, the histone deacetylases HDAC1 and HDAC2, histone binding proteins RbAp46 and RbAp48, as well as other polypeptides.

Reveal the correlation between hub hypoxia/immune-related genes and immunity and diagnosis, and the effect of SAP30 on cell apoptosis, ROS and MDA production in cerebral ischemic stroke. SAP30 promotes breast tumor progression by bridging the transcriptional corepressor SIN3 complex and MLL1.

Jun 11, 2024 · We found Sin3A-associated protein 30 (SAP30), a driver transcription factor positively associated with high-risk, progression, stage 4, and poor survival in neuroblastoma patient cohorts. Tumors of high-risk neuroblastoma patients and relapse-specific patient-derived xenografts showed higher SAP30 levels.

Sep 1, 2023 · SAP30 enhanced chromatin accessibility and RNA polymerase II occupancy at promoters in breast cancer cells, acting as a coactivator for genes involved in cell motility, angiogenesis, and lymphangiogenesis, thereby driving tumor progression.

Dec 6, 2024 · SAP30-mediated autophagy enhances cell growth and provides protection in NB cells treated with chemotherapy drugs. Notably, suppressing SAP30 in vivo increases LC3B accumulation, an autophagy marker, along with reduced proliferation markers, both in vivo and in PDX tumors. Therefore, SAP30 emerges as a potential target to enhance NB ...

SAP30 induced cell death in vitro and led to a reduced tumor burden and size in vivo. Altogether, these results indicate that SAP30 is a better prognostic and cisplatin-resistance marker and thus a potential drug target in high-risk neuroblastoma. INTRODUCTION Neuroblastoma (neuro, nerve; blastoma, cancer) is a rare cancer that

Here, we identify SAP30 as a novel component of the human histone deacetylase complex that includes Sin3, the histone deacetylases HDAC1 and HDAC2, histone binding proteins RbAp46 and RbAp48, as well as other polypeptides.

Jun 11, 2024 · We identified Sin3A-associated protein 30 (SAP30), a transcription factor meeting each of these criteria, using neuroblastoma patient datasets (The Genomics of Drug Sensitivity in Cancer and The Cancer Cell Line Encyclopedia) and CRISPR-Cas9 screens through robust bioinformatic pipelines.