Mar 30, 2025 · SAP18 (Sin3A Associated Protein 18) is a Protein Coding gene. Diseases associated with SAP18 include Basal Cell Nevus Syndrome 1 and Pallister-Hall Syndrome. Among its related pathways are Processing of Capped Intron-Containing Pre-mRNA and RNA Polymerase I Promoter Opening.

Jul 24, 2023 · As a part of EJC, SAP18 mediates alternative splicing events and suppresses the cryptic splice sites present within flanking regions of exon-exon junctions. In this review, we provide a thorough discussion on SAP18, focussing on its conserved dual role in transcriptional regulation and messenger RNA splicing.

Jan 22, 2019 · Our data suggest a novel mechanism of vFLIP activation of the NF-κB by decreasing the SAP18/HDAC1 complex to promote the acetylation of p65 subunit, which contributes to vFLIP-induced...

Jan 13, 2025 · Dynamic shuttling of proteins between the nucleus and cytoplasm orchestrates vital functions in eukaryotes. Here, we reveal the multifaceted functions of Arabidopsis Sin3-associated protein 18 kDa (SAP18) in the regulation of development and heat-stress tolerance.

Jul 24, 2023 · In this review, we provide a thorough discussion on SAP18, focussing on its conserved dual role in transcriptional regulation and messenger RNA splicing. Recent research on the involvement of SAP18 in the emergence of cancer …

Oct 3, 2006 · The protein SAP18 (Sin3-associated polypeptide of 18 kDa) has been shown to play a key role in gene-specific recruitment of the HDAC complex by a number of transcription factors including Gli, GAGA, and Bicoid.

Histone deacetylase complex subunit SAP18 is an enzyme that in humans is encoded by the SAP18 gene. [5][6]

Feb 8, 2025 · Functional role of SAP18 protein: From transcriptional repression to splicing regulation. These studies indicated that SAP18 expression enhanced the recruitment of mSin3A in coordination with TRIB1 to MTTP regulatory elements and increased MTTP expression.

Jan 4, 2025 · Gene target information for SAP18 - Sin3A associated protein 18 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

SAP18 is another polypeptide originally discovered by biochemical fractionation of human cell extracts and found to co-purify with the Sin3A/RPD3 HDAC complex in the enhancement of Sin3-mediated repression.