The PEMT enzyme converts phosphatidylethanolamine (PE) to phosphatidylcholine (PC) via three sequential methylations by S-adenosyl methionine (SAM). The enzyme is found in …

Feb 17, 2016 · Pemt is methyltransferase, which converts phosphatidylethanolamine to phosphatidylcholine using S-adenosylmethionine (SAM) as a methyl donor and the knockout …

S-Adenosylmethionine (SAM) provides methyl groups required by PEMT to convert phosphatidylethanolamine (PE) into phosphatidylcholine (PC). The ‘A’ allele of G523A in …

Apr 20, 2017 · S-adenosylmethionine (SAM) is the methyl donor for biological methylation modifications that regulate protein and nucleic acid functions. Here, we show that methylation …

Here, we show that methylation of a phospholipid, phosphatidyleth-anolamine (PE), is a major consumer of SAM. The induction of phospholipid biosynthetic genes is accompanied by …

Feb 7, 2018 · Here, we show that Pemt and Gnmt, key one-carbon cycle genes regulating PC/SAM levels, are downregulated after feeding, leading to decreased PC and increased SAM …

The human requirement for choline can be met in part through the endogenous biosynthesis of phosphatidylcholine. Specifically, phosphatidylethanolamine N-methyltransferase (PEMT) …

Jun 1, 2023 · Studies have shown that PEMT-/-mice increased susceptibility of diet-induced fatty liver and steatohepatitis. However, knockout of PEMT protects against diet-induced …

Mar 1, 2013 · Phosphatidylethanolamine N -methyltransferase (PEMT) catalyzes the methylation of phosphatidylethanolamine to phosphatidylcholine (PC). This 22.3 kDa protein is localized to …

Oct 16, 2013 · Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3 …