SAGA and ATAC histone acetyl transferase complexes regulate …
Nov 4, 2011 · Histone acetyltransferase (HAT) complexes are coactivators that are important for transcriptional activation by modifying chromatin. Metazoan SAGA and ATAC are distinct …
The related coactivator complexes SAGA and ATAC control
Aug 24, 2021 · SAGA (Spt-Ada-Gcn5 acetyltransferase) and ATAC (Ada-two-A-containing) are two related coactivators, sharing the same histone acetyltransferase (HAT) enzyme, either …
ATAC-king the complexity of SAGA during evolution - PMC
During evolution, the yeast coactivator SAGA complex, which is involved in the regulation of gene expression and histone modification, has diverged into numerous distinct protein complexes in …
SAGA and ATAC Histone Acetyl Transferase Complexes Regulate …
Nov 4, 2011 · The metazoan ATAC (Ada-Two-A-Containing) and SAGA (Spt-Ada-Gcn5-Acetyl-transferase) complexes are distinct multisubunit coactivators that share several subunits …
ATAC and SAGA co-activator complexes utilize co-translational …
Here, we demonstrate that the core modules of ATAC (ADA-two-A-containing) and SAGA (Spt-Ada-Gcn5-acetyltransferase), two lysine acetyl transferase-containing transcription co …
Targeting the SAGA and ATAC transcriptional coactivator …
SAGA and ATAC subunits provide unique targets for potential therapy development. Both complexes contain multiple enzymatic activities, the HAT and DUB modules in SAGA and the …
The related coactivator complexes SAGA and ATAC control …
SAGA (Spt-Ada-Gcn5 acetyltransferase) and ATAC (Ada-two-A-containing) are two related coactivator complexes, sharing the same histone acetyltransferase (HAT) subunit. The HAT …
Targeting the SAGA and ATAC Transcriptional Coactivator Complexes in ...
May 15, 2020 · This review summarizes key findings on the roles of SAGA and ATAC in embryo development and in cancer to better understand the functional relationships of these …
KAT2A complexes ATAC and SAGA play unique roles in cell …
Jan 7, 2022 · In AML cells, ATAC and SAGA controlled distinct aspects of biosynthetic maintenance and identity preservation of leukemia cells, thus suggesting a dichotomy between …
ATAC and SAGA histone acetyltransferase modules facilitate ...
Dec 4, 2024 · Two key human transcriptional coactivator complexes, ATAC (ADA-two-A-containing) and SAGA (Spt-Ada-Gcn5 acetyltransferase), containing histone acetyltransferase …