Jan 22, 2018 · STIM2 (stromal interaction molecule 2) protein expression is upregulated in pulmonary artery smooth muscle cell (PASMC) from patients with pulmonary arterial hypertension (PAH) compared with PASMC from normal subjects and is sufficient and necessary for increasing the resting [Ca 2+] cyt in PASMCs.

Herein, we sum the latest findings on the STIM2 structure, focusing on its distinct characteristics and profound effect on the regulation of Ca 2+ homeostasis and multi-talented functionality.

Here, we report that STIM2, a Ca 2+ sensor in the sarcoplasmic reticulum (SR) membrane, is required for raising the resting [Ca 2+] cyt in PASMCs from patients with pulmonary arterial hypertension (PAH) and activating signaling cascades that stimulate PASMC proliferation and inhibit PASMC apoptosis.

An endoplasmic reticulum (ER)‐resident protein that regulates cytosolic and ER free‐Ca2+ concentration by induction of store‐operated calcium entry: that is the original definition of STIM2 and its function. While its activity strongly depends on ...

Downregulation of STIM2 in PAH-PASMCs with siRNA (1) decreases the level of pCREB, pSTAT3, and pAKT and inhibits NFAT nuclear translocation, thereby attenuating proliferation, and (2) decreases Bcl-2, which leads to an increase of apoptosis.

Jun 9, 2018 · In summary, these data indicate that upregulated STIM2 in PAH-PASMCs, by raising the resting [Ca 2+] cyt, contributes to enhancing PASMCs proliferation by activating the CREB, STAT3, AKT and NFAT signaling pathways and promoting the transition of PASMCs from the quiescent phase to mitosis.

Jan 22, 2018 · In summary, these data indicate that upregulated STIM2 in PAH-PASMCs, by raising the resting [Ca 2+] cyt, contributes to enhancing PASMC proliferation by activating the CREB, STAT3, AKT, and NFAT signaling pathways and stimulating PASMC proliferation.

Oct 3, 2018 · Overexpression of STIM2 in normal PASMCs increased basal [Ca 2+] cyt, phosphorylated-Akt and mTOR levels, and enhanced the activation of CREB, STAT3 and NFATc2, which are Ca 2+ /calmodulin-sensitive transcription …

Enhanced STIM2 protein levels promote SMC proliferation and vascular remodeling by activating a variety of transcription factors, including NFAT, CREB, STAT3, and AKT, even in the absence of ...

Using biochemical, microscopic, and genetic approaches, we demonstrate that the stromal interaction molecule (STIM)2, a calcium sensor, acts as a novel regulator of CaMKK2-AMPK signaling. We reveal that STIM2 interacts with AMPK and CaMKK2 and that the increase in intracellular calcium levels promotes AMPK colocalization and interaction with STIM2.