EMT regulators such as ZEB1/2 proteins, TGF-β, Twist, Snail and Slug are affected by STAT3 signaling to stimulate cancer migration and invasion. Different molecular pathways such as miRNAs, lncRNAs and circRNAs modulate STAT3/EMT axis.

Research over the last decade has established the importance of an ever-expanding list of master EMT transcription factors, whose activity is regulated by STAT3 and function to stimulate the rapid transition of cells between epithelial and mesenchymal phenotypes.

Our findings show that the JAK/STAT3 pathway is required for TGF-β-induced EMT and cancer cell migration and invasion via upregulation of the expression of p-Smad3 and Snail, and the IL-6/JAK/STAT3 and TGF-β/Smad signaling synergistically enhance EMT in lung carcinomas.

Aug 1, 2022 · Present review focuses on STAT3 and EMT interaction in modulating cancer migration. First of all, STAT3 is an upstream mediator of EMT and is able to induce EMT-mediated metastasis in brain tumors, thoracic cancers and gastrointestinal cancers.

Dec 1, 2020 · Our data show that BM-MSCs elicit EMT in epithelial-type cells through the IL-6/pY705-STAT3 pathway and induce MET in mesenchymal-type cells through LIFR/pS727-STAT3 signaling.

Dec 3, 2015 · In addition to its traditional role in cancer cell proliferation, invasion and migration, STAT3 also promotes cancer through altering gene expression via epigenetic modification, inducing...

Aug 1, 2022 · Present review focuses on STAT3 and EMT interaction in modulating cancer migration. First of all, STAT3 is an upstream mediator of EMT and is able to induce EMT-mediated metastasis in brain tumors, thoracic cancers and gastrointestinal cancers.

Recently, signal transducer and activator of transcription 3 (STAT3) activation has been linked to EMT program in breast cancer. However, the actual association of STAT3 activation with EMT, and its mediated tumor invasion and metastasis remains elusive in …

The crosstalk between STAT3 and p53/RAS signaling controls cancer cell metastasis and cisplatin resistance via the Slug/MAPK/PI3K/AKTmediated regulation of EMT and autophagy.

Jan 20, 2024 · STAT3 activation induces the EMT and promotes generation of CSCs through upregulating EMT associated transcription factors including Snail, Zeb1, JUNB, and Twist-1 or Nanog/slug axis [165].