Jan 1, 2017 · Based on studies in mice and data from human patients, STAT1 is generally considered a tumour suppressor but there is growing evidence that it can also act as a tumour promoter. This review aims at contrasting the two faces of STAT1 in tumourigenesis and providing an overview on the current knowledge of the underlying mechanisms or pathways. 1.

The majority of evidence shows that activating STAT1 plays a tumor suppressor role in cancer cells. Nevertheless, results from some experiments and clinical studies suggest that STAT1 also exerts tumor promoter effects under specific conditions.

STAT1 plays a critical role in tumorigenesis by controlling a complex array of activities and functions. In many types of tumors STAT1 induces anti-proliferative and pro-apoptotic genes that directly hamper tumor growth.

STAT1 and STAT2 are the first STAT proteins identified in the IFN signal transduction pathways that have an essential role in suppressing tumor cell proliferation, differentiation, apoptosis and angiogenesis.

Existing evidence reveals that STAT1 has both tumor-suppressing and tumor-promoting functions involved in angiogenesis, cell proliferation, migration, invasion, apoptosis, drug resistance, stemness, and immune responses mainly through interacting and …

May 20, 2022 · STAT1 siRNA knockdown in human HNSCC cells impaired their proliferation and expression of the immunosuppressive marker PD-L1. Stat1 -deficient mice displayed increased oral lesion incidence and...

Nov 23, 2023 · Dysregulation of STATs is frequently observed in tumors and can directly drive cancer pathogenesis. STAT1 and STAT3 are generally viewed as mediating opposite roles in cancer development, with STAT1 suppressing tumorigenesis and STAT3 promoting oncogenesis.

Jan 3, 2023 · STAT proteins (notably STAT3, and to a lesser extent STAT1) are essential for regulating the cancer-promoting activities of S1P, S1PR1 and/or sphingosine kinases in cancer cells and/or tumour ...

May 31, 2012 · Although the activation of STAT1 by IFNs is classically associated with antiviral defense and tumor-suppressive functions, emerging data indicate that expression of the STAT1 pathway confers cellular resistance to DNA-damaging agents …

Mar 20, 2024 · Silencing of TP63 enhances the anti-tumor efficacy of PD-1 blockade by promoting CD8 + T cell infiltration and functionality. Mechanistically, TP63 and STAT1 mutually suppress each other to regulate the IFNγ signaling by co-occupying …