Nov 26, 2021 · There are 4 members in the JAK family: JAK1, JAK2, JAK3, and TYK2. The STAT family comprises seven members: STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, and STAT6. We introduce them by family. JAK...

Feb 19, 2019 · Mutations in the kinases that phosphorylate STAT5, and/or overexpression of the upstream receptor-associated tyrosine kinases have been suggested as the main drivers of constitutive STAT5...

First, IL-2-STAT5 signaling has been shown to repress expression of the IL-6R subunits IL-6Rα and gp130, leading to a reduction in IL-6 responsiveness and STAT3 activation (78, 83, 136). STAT5 also competes directly with STAT3 for binding at the Bcl6 promoter to …

Jan 15, 2005 · These findings provide the first evidence for a function of STAT3 and STAT5A/B in the IFN-alphabeta response, and support a model in which the IFN-alphabeta receptor initiates both pro- and antiapoptotic responses through STAT1, and STAT3 and STAT5A/B, respectively.

Our results show that patients having the IRF2BP2 c.625_665del mutation presented overexpression of STAT1 protein and increased constitutive activation of STAT1. In addition, interferon-induced JAK–STAT signaling was upregulated, and several interferon-inducible genes were overexpressed.

For instance, IL-2, IL-7 and IL-21 each can activate STAT1, STAT3 and STAT5, but IL-2 promotes much stronger STAT5 activation, IL-7 induces persistent STAT5 activation, while IL-21 produces far more activated STAT3. 46 Further, heterodimerization of STAT5 isoforms 5a and 5b has been shown in response to IL-2 as well as IL-7, showing that while ...

Aug 22, 2003 · Using mouse embryonic fibroblasts with targeted disruption of the Stat5a and Stat5b genes, we demonstrate that full activation of Stat5 is required for Type I interferon-dependent gene transcription via GAS elements.

Dec 7, 2001 · In this paper we show that Stat5 activation by the IFN-γ receptor results from a promiscuity of the amino acids surrounding Tyr-420 and Tyr-440 of, respectively, the murine and human IFNGR1 chains for Stat1 and Stat5 association.

Jan 15, 2005 · In this study, we demonstrate that IFN-αβ, although antiproliferative in wild-type CD4 + or CD8 + T cells, act as strong mitogens on their STAT1 −/− counterparts. Furthermore, IFN-αβ exert little effect on apoptosis in wild-type cells, but are potent survival factors in the absence of STAT1.

Dec 7, 2001 · Signal transduction via the interferon-gamma (IFN-gamma) receptor requires the tyrosine phosphorylation of signal transducers and activators of transcription (Stats). Whereas tyrosine phosphorylation of Stat1 occurs in all cells, activation of …