Jul 1, 2013 · STAT1 and STAT2 proteins are key mediators of type I and type III interferon (IFN) signaling, and are essential components of the cellular antiviral response and adaptive immunity. They associate with IFN regulatory factor 9 (IRF9) to form a heterotrimeric transcription factor complex known as ISGF3 …

STAT1 and STAT2 proteins are key mediators of type I and type III interferon (IFN) signaling, and are essential components of the cellular antiviral response and adaptive immunity. They associate with IFN regulatory factor 9 (IRF9) to form a heterotrimeric transcription factor complex known as …

STAT1 is the major mediator of the cellular response to interferons (IFNs) [4, 5]. It plays a key role in the immune response against viruses and mycobacteria by transducing in the nucleus the signal from type I IFNs (IFNα, IFNβ, IFNε, IFNκ, and IFNω), type II …

Sep 25, 2020 · Serine/threonine phosphorylation of STAT2 by glycogen synthase kinase 3 α/β (GSK3α/β) enhances the recruitment of the S-phase kinase-associated protein 1 (SKP1)-cullin 1 (CUL1)-F-box...

Aug 5, 2020 · Using electron microscopy, we found that, in naive cells, U-STAT2, lacking the activating tyrosine phosphorylation, forms a heterodimer with U-STAT1 in an inactive, anti-parallel conformation.

STAT1 has a key role in many gene expressions that cause survival of the cell, viability or pathogen response. There are two possible transcripts (due to alternative splicing) that encode 2 isoforms of STAT1.

Signal transducer and activator of transcription 2 is a protein that in humans is encoded by the STAT2 gene. [ 5 ] [ 6 ] It is a member of the STAT protein family. This protein is critical to the biological response of type I interferons (IFNs). [ 7 ]

Oct 25, 2016 · Our results uncover STAT2 as a pervasive cytokine regulator due to its inhibition of STAT1 in multiple signaling pathways and provide an understanding of the type 1 interferon-independent activities of this protein.

Jun 1, 2016 · STAT2/IRF9 directs a prolonged ISGF3-like transcriptional response and antiviral activity in the absence of STAT1. In the canonical pathway of IFN-I-mediated signaling, phosphorylation of STAT1 and STAT2 leads to heterodimerization and interaction with IRF9.

Type I interferons (IFN-I) protect us from viral infections. Signal transducer and activator of transcription 2 (STAT2) is a key component of interferon-stimulated gene factor 3 (ISGF3), which drives gene expression in response to IFN-I.