Signal transducer and activator of transcription 1 (STAT1) is a transcription factor which in humans is encoded by the STAT1 gene. It is a member of the STAT protein family. [5]

Mar 30, 2025 · STAT1 (Signal Transducer And Activator Of Transcription 1) is a Protein Coding gene. Diseases associated with STAT1 include Immunodeficiency 31C and Immunodeficiency 31B . Among its related pathways are IL-9 Signaling Pathways and Prolactin Signaling .

STAT1 is the major mediator of the cellular response to interferons (IFNs) [4, 5]. It plays a key role in the immune response against viruses and mycobacteria by transducing in the nucleus the signal from type I IFNs (IFNα, IFNβ, IFNε, IFNκ, and IFNω), type II …

Members of the signal transducer and activator of transcription (STAT) protein family are intracellular transcription factors that mediate many aspects of cellular immunity, proliferation, apoptosis and differentiation.

Nov 26, 2021 · JAKs are noncovalently associated with cytokine receptors, mediate tyrosine phosphorylation of receptors, and recruit one or more STAT proteins. Tyrosine-phosphorylated STATs dimerize and are...

The STAT1 gene provides instructions for making a protein that is involved in multiple immune system functions, including the body's defense against a fungus called Candida . Learn about this gene and related health conditions.

A monoclonal STAT1 N-terminal antibody (indicated as STAT1-N) was used to visualize the STAT1–STAT3 chimeric protein. A STAT3 C-terminal antiserum (indicated as STAT3-C) was employed to detect both the STAT1–STAT3 chimera and the endogenous STAT3.

STAT1 transduces signals from cytoplasmic domains of transmembrane receptors into the nucleus where it regulates gene expression. Thereby it modulates diverse cellular processes, such as proliferation, differentiation and cell death. STAT1 function is central in the innate and adaptive arm of immunity and protects from pathogen infections [2].

Apr 7, 2022 · The signal transducer and activator of transcription (STAT) 1 protein plays a key role in the immune response against viruses and other pathogens by transducing, in the nucleus, the signal from type I, type II and type III IFNs.

Mar 18, 2025 · To antagonize IFN signaling, P-protein interacts directly with STAT1 through its P-CTD . Note that the efficient interaction of P-protein with STAT1 in cells depends on activation of the cells by IFN-α, IFN-β, or IFN-γ, suggesting that P-CTD binds more efficiently to pY-STAT1 than to nonphosphorylated STAT1 (28, 29, 33, 36, 37). However, the ...