The STAT1 KO mice succumbed to mycobacterial infection by the 35th day after infection. Compared with the levels in WT mice, inducible nitric oxide synthase (iNOS), tumor necrosis factor-alpha, interferon-gamma and IL-12 mRNA levels were significantly lower in the lung of STAT1 KO mice.

Jan 1, 2009 · STAT1 Knockout (KO) Mice IFNs regulate cellular antiviral, antiproliferative and immunological responses. There are two types of IFNs, Type-I (IFN-α and IFN-β) and Type-II (IFN-γ).

These mice may be useful for studying the mechanisms of IFN-induced and STAT1-dependant resistance to infection. Homozygous ( Stat1 -/- ) mice are viable and fertile when maintained under specific pathogen-free (SPF) conditions.

Need high-titer viral stocks for vaccine or gene therapy development? Explore our resources below to discover how STAT1 and BAX knockout cell lines can help.

Vero.STAT1 KO is a CRISPR/Cas9 genome-edited STAT1 knockout cell line that exhibits significantly increased virus production capacity for viral vaccine manufacturing.

Aug 9, 2019 · The results show significant reduction in type 1 ISG expression relative to the STAT1 KO alone. Our results suggest that STAT1 and STAT2 are obligatory involved in all type 1 IFN related activities in HeLa cells. To prove this assumption, we …

Genes down-regulated in CD8 T cells: STAT1 [GeneID=6772] knockout versus STAT4 [GeneID=6775] knockout. Type 1 IFNs can conditionally activate all of the signal transducers and activators of transcription molecules (STATs), including STAT4.

Frieman MB, Chen J, Morrison TE, Whitmore A, Funkhouser W, Ward JM, Lamirande EW, Roberts A, Heise M, Subbarao K, Baric RS, SARS-CoV pathogenesis is regulated by a STAT1 dependent but a type I, II and III interferon receptor independent mechanism.

MDCK.STAT1 KO is an excellent cell model for virus propagation and viral vaccine production. It exhibits significant increased viral titer and enhanced virus production capability when compared to its parental cell line. Figure 1: Influenza A (H1N1; ATCC® VR-1736TM) produced in …

Oct 15, 2014 · The current studies examined the effect of STAT1 deletion in murine models of protective immunity to C. neoformans. Survival and fungal burden were evaluated in wild-type and STAT1 knockout (KO) mice infected with either strain H99γ or C. neoformans strain 52D (unmodified clinical isolate).