The majority of evidence shows that activating STAT1 plays a tumor suppressor role in cancer cells. Nevertheless, results from some experiments and clinical studies suggest that STAT1 …

Jan 1, 2017 · A correlation of STAT1 expression with good prognosis has been shown in several types of cancers, including colo (rectal) cancer [23], [24], [25], [26], hepatocellular carcinoma …

STAT1 and STAT2 are the first STAT proteins identified in the IFN signal transduction pathways that have an essential role in suppressing tumor cell proliferation, differentiation, apoptosis and …

Jan 3, 2023 · Elevated expression of NAMPT in cancer cells increases NAD + biogenesis and α-ketoglutarate levels, resulting in upregulation of PDL1 via the STAT1–interferon-γ (IFNγ) axis.

Here we review the functional canonical and non canonical effects of STAT1 and STAT3 activation in tumorigenesis and their potential cross-regulation mechanisms and discuss the …

STAT1 has been identified to have prognostic value in patients with solid cancer. Highly expressed STAT1 may predict prognosis in cancer patients based on their tumor types. …

Existing evidence reveals that STAT1 has both tumor-suppressing and tumor-promoting functions involved in angiogenesis, cell proliferation, migration, invasion, apoptosis, drug resistance, …

Oct 9, 2016 · STATs are dysregulated in a broad range of cancer types. Although the genes that encode STATs are rarely mutated in cancer, constitutive phosphorylation and hence activation …

Sep 30, 2024 · Imaging technique reveals STAT1-mediated activation of engineered NK cells, offering a novel method to monitor antitumor activity and enhance the effectiveness of NK cell …

May 20, 2022 · Our findings indicate that STAT1 activity plays an important role in tumorigenicity and immunosuppression during HNSCC development. Head and neck squamous cell …