Our study indicated that the STAT1-CCL5 axis is an important modulator in the development of CRC through promoting cell proliferation. Moreover, the levels of STAT1 and CCL5 might be valuable biomarkers for CRC screening.

Our study indicated that the STAT1-CCL5 axis is an important modulator in the development of CRC through promoting cell proliferation. Moreover, the levels of STAT1 and CCL5 might be valuable biomarkers for CRC screening.

Nov 1, 2022 · The mRNA levels of STAT1 and CCL5 were significantly elevated in CRC tissue specimens, and the upregulation of STAT1-CCL5 axis promoted the proliferation of CRC cells. Tumor buds, CCL5, and fibroblasts further promote angiogenesis and collagen synthesis, ultimately creating a tumor-friendly microenvironment.

Thus, our study reveals a mechanism of IL-27 induction of CCL5 in T cells: in CD4 + T cells, CCL5 induction is Stat1-dependent, while in CD8 + T cells, induction of CCL5 is mediated by Stat1 in early stages, while persistent induction of CCL5 requires activation of Stat3.

Dec 4, 2019 · C-C motif chemokine ligand 5 (CCL5), which is secreted by macrophages, inhibited T-cell-mediated killing of HT29 cells and promoted immune escape by stabilizing PD-L1 in vitro and in...

The results from the TCGA and GTEx databases showed that the mRNA levels of STAT1 and CCL5 were significantly elevated in CRC tissues compared with normal colon tissues (Figure 8). In addition,...

In other gene-pairs, such as GAPDH-STAT1, the dependence is clearer in the whole cohort rather than in T cells, probably due to the effect of cell-type bound expressions described above. Interestingly, all the chemokines in this analysis—CCL4, CCL5, and CCR7— have an …

Mar 22, 2022 · These reports indicate the tumor suppressive roles of STAT1 in CRC. In contrast, STAT1 has been shown to induce the proliferation of CRC through the upregulaiton of the STAT1-CCL5 axis . It has also been reported that STAT1 promotes KRAS colon tumor growth by downregulating programmed cell death protein 4 .

Dec 5, 2024 · CCL5 also sustained Stat1 activation by inhibiting its dephosphorylation through reduced interaction with SHP2, leading to prolonged inflammatory signaling. Single-cell transcriptomics confirmed high CCR5 expression in macrophages, correlating with …

Aug 14, 2020 · STAT1 expression was highly positively correlated with the level of CCL5. The results of the cell counting, EdU, CCK-8, and CFSE staining assays showed that interfering with STAT1 and CCL5 could inhibit the proliferation of CRC cells.