Jan 7, 2020 · Group 2 ILCs (ILC2s) express lineage transcription factor GATA3 and produce interleukin 5 (IL-5) and IL-13 4, 5. In mice, ILC2s appear to be the most homogeneous subset …

In mice, ILC2s have been described as Lin-Sca-1 + CD127 + CD117 + ST2 + ICOS + cells that also typically express CD90/Thy1, IL-17 RB, and CD25/IL-2 R alpha. In humans, ILC2s are …

Oct 22, 2015 · We demonstrate that CD25 + ILCs that produce type 2 cytokines (ILC2s) are present in the aorta of atherosclerotic immunodeficient ldlr −/− rag1 −/− mice.

Nov 2, 2022 · Sorted single and viable lung ILC2s defined as lineage − CD90 + CD127 + CD25 + ST2 + cells were cultured for 10 days in the presence of IL-2, IL-7, IL-25 and IL-33 (each at 10 …

IL-17 plays a pathogenic role in asthma. ST2 − iILC2s (inflammatory group 2 innate lymphoid cells) driven by IL-25 can produce IL-17, while ST2 + nILC2s (natural ILC2s) produce few IL …

We demonstrate that unconventional ST2- and CD127-negative ILC2 populations are present in mouse lung and are induced by Alternaria, suggesting commonly used ILC2 identification …

ST2 − inflammatory group 2 innate lymphoid cells (ILC2s) driven by IL-25 can produce IL-17, whereas ST2 + natural ILC2s produce little IL-17. We characterized ST2 + IL-17 + ILC2s …

Mar 30, 2022 · ST2 knockout (KO) reduces Treg frequencies, enlarges brain lesion size and exacerbates functional deficits after TBI. (A) Representative gating strategy for CD4 + T cells, …

Dec 10, 2024 · HIF2α activity promotes the differentiation of a Ly108 stem-like Th2 cell population to develop into CD25 ST2 pathogenic Th2 cells through cooperation with GATA3 to induce …

Group 2 ILCs (ILC2s) express lineage transcription factor GATA3 and produce interleukin 5 (IL-5) and IL-13 4, 5. In mice, ILC2s appear to be the most homogeneous subset so far; they are …