Mar 19, 2021 · Somatostatin (SST) is a well-known neuropeptide that is expressed throughout the brain. In the cortex, SST is expressed in a subset of GABAergic neurons and is known as a...

May 26, 2016 · Somatostatin-expressing GABAergic neurons constitute a major class of inhibitory neurons in the mammalian cortex and are characterized by dense wiring into the local network and high basal...

Mar 19, 2025 · Explore how SST neurons contribute to neurocircuit regulation, highlighting their molecular traits, receptor interactions, and role in neurotransmission. Somatostatin (SST) neurons play a key role in regulating neural circuits by modulating inhibitory signaling within the brain.

6 days ago · Activation of SST neurons in the HBX generated antidepressant action. To explore cell-type-specific neurons that causally influence both the induction and relief of multiple depression-related ...

In this study, using SST interneurons as an exemplar, we propose connectivity as an organizing principle that synthesizes noisy cellular features into meaningful cell types.

In the nervous system, SST acts as a neuromodulator and neurotransmitter affecting, among others, memory, learning, and mood. In the sensory cortex, the co-localisation of GABA and SST is found in approximately 30% of interneurons.

Feb 1, 2025 · Somatostatin-expressing (SST) neurons are a major class of electrophysiologically and morphologically distinct inhibitory cells in the mammalian neocortex. Transcriptomic data suggest that this class can be divided into multiple subtypes that are correlated with morpho-electric properties.

For GABAergic inhibitory neurons within the cortex, 37 clusters were summarized to 7 groups according to the expression of Lamp5, Sncg, Reln, Vip, Pvalb, Sst, and Chodl genes, marking key GABAergic neuron subtypes 28, 34 (Figure S6H). Among these GABAergic neurons, Pvalb and Sst neurons were dominant in the mouse cortex (Figures S6I–S6K).

Jul 6, 2018 · We found that somatostatin (SST) neurons in the TN, which is known to exhibit pathological or cytological changes in human neurodegenerative diseases, play a crucial role in regulating feeding in mice. GABAergic tuberal SST (TN SST) neurons were activated by hunger and by the hunger hormone, ghrelin.

Mar 25, 2025 · PV and Sst inhibitory interneurons exhibited distinct correlations to gamma oscillations. PV cells were strongly phase locked, while Sst cells were weakly phase locked, except for narrow-waveform Sst cells. PV cells fired at a substantially earlier phase in the gamma cycle (≈6 ms) than Sst cells.