Feb 10, 2018 · The scavenger receptor, class B type 1 (SR-B1), is a multiligand membrane receptor protein that functions as a physiologically relevant high-density lipoprotein (HDL) receptor whose primary role is to mediate selective uptake or influx of HDL-derived cholesteryl esters into cells and tissues.

When binding to its ligand HDL, SR-B1 regulates macrophage inflammation through activation of Akt and reduces activation of NF-κB, leading to increased anti-inflammatory cytokines such as interleukin (IL)-10 and transforming growth factor-beta (TGF-β).

SR-B1 interaction with HDL modulates macrophage inflammation through activation of Akt and decreased activation of nuclear factor-κB (NF-κB), promoting the release of anti-inflammatory cytokines, including interleukin 10 and transforming growth factor-beta (TGF-ß) [26,39].

Scavenger receptor B type 1 (SR-B1) is a cell surface HDL receptor that mediates HDL-CE uptake. It is most abundantly expressed in liver, where it provides cholesterol for bile acid synthesis, and in steroidogenic tissues, where it delivers cholesterol needed for storage or steroidogenesis in rodents.

Apr 24, 2019 · Here we show in mice that scavenger receptor class B type 1 (SR-B1) in endothelial cells mediates the delivery of LDL into arteries and its accumulation by artery wall macrophages, thereby...

These show SR-B1 and PDZK1 play key roles in HDL metabolism and protection against atherosclerosis. The recent identification of rare loss of function mutations in the human SCARB1 gene verifies that it plays similar roles in HDL metabolism in humans.

The scavenger receptor, class B type 1 (SR-B1), is a multiligand membrane receptor protein that functions as a physiologically relevant high-density lipoprotein (HDL) receptor whose primary role is to mediate selective uptake or influx of HDL-derived cholesteryl esters into cells and tissues.

Purpose of review: The binding of high-density lipoprotein (HDL) to its primary receptor, scavenger receptor class B type 1 (SR-B1), is critical for lowering plasma cholesterol levels and reducing cardiovascular disease risk. This review provides novel insights into how the structural elements of SR-B1 drive efficient function with an emphasis ...

SR-B1 serves as the primary receptor for high-density lipoproteins (HDL) and mediates bidirectional cholesterol transport between HDL and cells. Specifically, SR-B1 selectively delivers cholesteryl esters (CE) into cells from HDL, without holoparticle uptake of HDL [4, 5]. SR-B1 also effluxes free cholesterol (FC) out of cells into HDL .

Sep 20, 2016 · Human SCARB1 gene variants are associated with a new lipid phenotype, characterized by high levels of both HDL cholesterol and Lp (a). SCARB1 exonic variants often result in diminished function of translated SR-B1 via …