Superoxide dismutase 2, mitochondrial (SOD2), also known as manganese-dependent superoxide dismutase (MnSOD), is an enzyme which in humans is encoded by the SOD2 gene on chromosome 6. [5][6] A related pseudogene has been identified on chromosome 1.

Superoxide dismutase 2, mitochondrial (SOD2) is a potent antioxidant enzyme which is encoded for by the SOD2 gene. SOD2 is one of three SOD enzymes found in humans, and as its name suggests SOD2 is expressed specifically in the mitochondria …

Mar 30, 2025 · SOD2 (Superoxide Dismutase 2) is a Protein Coding gene. Diseases associated with SOD2 include Microvascular Complications Of Diabetes 6 and Gastric Cancer. Among its related pathways are Gene expression (Transcription) and Defective Intrinsic Pathway for …

Sod2 is critical to cellular function in metabolically active tissues, particularly neurons. Neurodegenerative disorders show the importance of the SOD2’s role against pathological stresses.

SOD2 A16V (Mitochondria)-Superoxide dismutase (SOD2, MnSOD) enzyme in the mitochondria that transforms O2- superoxide free radical into diatomic oxygen (02) or hydrogen peroxide (H202). The removal of superoxide free radical reduces oxidative stress.

Feb 8, 2025 · Gene target information for SOD2 - superoxide dismutase 2 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

Superoxide dismutase 2 scavenges ROS to promote osteogenic differentiation of human periodontal ligament stem cells by regulating Smad3 in alveolar bone-defective rats. SOD2 promotes the immunosuppressive function of mesenchymal stem cells at the expense of adipocyte differentiation.

Feb 8, 2025 · This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit.

Dec 14, 2019 · SOD2 (also called MnSOD) is often viewed as the most important form of SOD in humans, especially in the brain. As its name suggests, SOD2 requires manganese (Mn) to work [2, 1]. SOD2 transforms superoxide produced by the mitochondria into the less toxic hydrogen peroxide and oxygen.

SOD2 Gene Detail Superoxide dismutases (SOD) play a role in the first step of managing oxidative stress and free radicals especially within the mitochondria. SODs are enzymes that catalyze the conversion of superoxide into hydrogen peroxide and oxygen.