
SOD2 and Cancer: The Enzyme’s Role in Tumor Metabolism
Explore how SOD2 influences tumor metabolism through its role in oxidative stress regulation, expression changes in cancer cells, and metabolic adaptations. Superoxide dismutase 2 (SOD2) is a mitochondrial enzyme that manages oxidative stress and influences tumor metabolism.
Mitochondrial Superoxide Dismutase: What the Established, the ...
We propose that mitochondrial superoxide dismutase (SOD2) is a major system converting diffusion-restricted superoxide radicals derived from the electron transport chain into highly diffusible hydrogen peroxide (H 2 O 2).
Insights into the Dichotomous Regulation of SOD2 in Cancer
While much is known about the transcriptional regulation of the SOD2 gene, including downregulation by epigenetics and activation by stress response transcription factors, further research is required to understand the post-translational modifications that …
Superoxide Dismutases: Role in Redox Signaling, Vascular …
Superoxide anion is dismutated by superoxide dismutases (SODs) to H 2 O 2 that is catalyzed to H 2 O by catalase, peroxiredoxins (Prxs), or glutathione peroxidases (GPx) (Fig. 1).
Regulation of SOD2 in Cancer by Histone Modifications and CpG ...
May 5, 2013 · In this review, we will specifically address epigenetic mechanisms underlying SOD2 transcriptional regulation, the metabolic consequences of SOD2 loss on cellular biology, and how these metabolic events promote further epigenetic instability during cancer development.
Mitochondrial SOD2 regulates epithelial–mesenchymal transition …
Feb 9, 2015 · Superoxide radicals in mitochondria are removed by the mitochondrial enzyme superoxide dismutase 2 (SOD2 aka manganese superoxide dismutase), generating hydrogen peroxide (H 2 O 2) and molecular...
SOD2 - Wikipedia
SOD2 uses cyclic proton-coupled electron transfer reactions to convert superoxide (O 2•-) into either oxygen (O 2) or hydrogen peroxide (H 2 O 2), depending on the oxidation state of the manganese metal and the protonation status of the active site.
Regulation of SOD2 in cancer by histone modifications and CpG ...
May 20, 2013 · Important recent advances in epigenetics research have indicated that the loss of SOD activity itself may contribute to changes in epigenetic regulation, establishing a vicious cycle that drives further epigenetic instability.
SOD2, the principal scavenger of mitochondrial superoxide, is ...
We therefore determined the impact of a high superoxide environment on cell size, progression through the cell cycle, cell differentiation, and cell death and found no difference between SOD2-null and SOD2+ larva and pupa.
SOD2, a Potential Transcriptional Target Underpinning CD44 …
Using cDNA oligo gene expression microarray, we identified SOD2 (superoxide dismutase 2) as a potential CD44-downstream transcriptional target involved in BC metastasis. SOD2 gene belongs to the family of iron/manganese superoxide dismutase family and encodes a …