SOD1 Rat | Taconic Biosciences
SOD1 rats in the Taconic colony have an average onset of motor neuron disease of 174-207 days, typically appearing as hind limb abnormal gait and progressing very quickly (6-9 days …
Preclinical Models to Support Newly Approved Therapy for ALS: The SOD1 Rat
Preclinical Support for Drug Development: The SOD1 Rat. The SOD1 rat is a hemizygous transgenic rat that overexpresses human SOD1 with the G93A mutation associated with …
002726 - SOD1-G93A Strain Details - The Jackson Laboratory
002726 B6SJL-Tg(SOD1*G93A)1Gur/J This strain ships with remnant UID MiniMax microchips implanted subcutaneously in the back.
Rodent Models of Amyotrophic Lateral Sclerosis - PMC
Rat models overexpressing mutant SOD1 have been generated as well and are particularly useful for evaluating therapeutic applications for which mice have been found to be too cumbersome …
SOD1 in ALS: Taking Stock in Pathogenic Mechanisms and the …
In the first model, mice carried the hSOD1(G93A) mutant under the control of the skeletal muscle-specific promoter from rat myosin light chain (MLC)-1, resulting in higher expression of the …
Delayed disease onset and extended survival in the SOD1G93A rat …
Nov 19, 2014 · Surprisingly, the knockdown of mutant SOD1 in only the motor cortex of presymptomatic SOD1(G93A) rats through targeted delivery of AAV9-SOD1-shRNA resulted …
Amyotrophic lateral sclerosis caused by SOD1 variants: from …
Pathogenic variants in the superoxide dismutase 1 (SOD1) gene were the first identified genetic cause of amyotrophic lateral sclerosis (ALS), in 1993. This discovery enabled the development …
Compared to wild type controls, transgenic SOD1 rats demonstrated detectable levels of human SOD1 expression. The onset of ALS-like symptoms in male and female SOD1G93A rats …
SOD1 and TDP-43 animal models of amyotrophic lateral
Jun 26, 2011 · To identify the mutant SOD1 gain of function, models have been created in mice, rats, zebrafish, Drosophila melanogaster, and Caenorhabditis elegans.
Disease progression of human SOD1 (G93A) transgenic ALS model rats
The recent development of a rat model of amyotrophic lateral sclerosis (ALS) in which the rats harbor a mutated human SOD1 (G93A) gene has greatly expanded the range of potential …