We measured plasma levels of SOD1 in healthy controls, patients with LCL (due to L. braziliensis or L. amazonensis), and patients with DCL (due to L. amazonensis) and investigated its …

SOD1 is a 32 kDa homodimer which forms a beta barrel (β-barrel) and contains an intramolecular disulfide bond and a binuclear Cu/Zn site in each subunit.

SOD1 is the major superoxide dismutase responsible for catalyzing dismutation of superoxide to hydrogen peroxide and molecular oxygen. It is well known as an essential antioxidant enzyme …

Aug 31, 2023 · SOD1 is a synthetic lethal vulnerability of PPM1D-mutant leukemia cells. CRISPR dropout screens have emerged as a powerful tool to assess the functional importance of …

Feb 10, 2023 · In this work, we want to highlight the modulation of SOD1 LLPS propensity in a Zn-dependent manner due to underlying conformational transitions between folded and partially …

Jul 7, 2014 · We measured plasma levels of SOD1 in healthy controls, patients with LCL (due to L. braziliensis or L. amazonensis), and patients with DCL (due to L. amazonensis) and …

As a SOD1 inhibitor, LCS-1 can significantly inhibit the viability and proliferation of DLBCL cell lines OCI-Ly18 and OCI-Ly19, and promote cell apoptosis, which provides a new idea for the …

Aug 1, 2022 · As expected, LCS-1 caused ROS production in a dose- and time-dependent manner. SOD1 inhibition also induced the gene expression of HO-1, GCLC, GCLM and NQO1 …

We identified superoxide dismutase-1 (SOD1) as a novel synthetic-lethal dependency of PPM1D which was validated by genetic and pharmacologic approaches. We showed that the mutant …

Aug 15, 2024 · We propose that LCS-1 forms an adduct with SOD1 that disrupts the intramolecular Cys 57 -Cys 146 disulfide bond and transforms SOD1 from a dismutase to an …