SOCS1, a member of SOCS family, is strongly induced upon TLR stimulation. Cells lacking SOCS1 are hyperresponsive to TLR stimulation. Thus, SOCS1 is an important regulator for both cytokine and TLR-induced responses.

SOCS1 and SOCS3 specific ways to inhibit TLR signaling: After LPS activates TLR4, signals are transmitted through the adaptor proteins including MyD88, MAL, TRIF and TRAM. Through MyD88 and MAL, NF-κB and MAPKs are activated by TRAF6 and TAK1, while IRF3 is activated by TRAM and TRIF.

Jun 15, 2018 · SOCS1 and SOCS3 strongly suppressed TLR7-mediated type I IFN production. Furthermore, we demonstrated that SOCS1- and SOCS3-bound IFN regulatory factor 7, a pivotal transcription factor of the TLR7 pathway, through the SH2 domain to promote its proteasomal degradation by lysine 48-linked polyubiquitination.

May 18, 2007 · Suppressor of cytokine signalling (SOCS) proteins are inhibitors of the Janus kinase–signal transducer and activator of transcription (JAK–STAT) pathways. SOCS1 also inhibits Toll-like receptor...

SOCS1 can regulate TLR-mediated signal transduction, yet mechanistic studies in murine macrophages have been confusing and contradictory. This study has used an adenoviral transfection system to determine the role of SOCS1 in the regulation of TNFα production by activated human monocytes.

Dec 1, 2008 · SOCS1 can regulate TLR-mediated signal transduction, yet mechanistic studies in murine macrophages have been confusing and contradictory. This study has used an adenoviral transfection system to determine the role of SOCS1 in the regulation of TNF-alpha production by activated human monocytes.

Apr 22, 2010 · SOCS1, a member of SOCS family, is strongly induced upon TLR stimulation. Cells lacking SOCS1 are hyperresponsive to TLR stimulation. Thus, SOCS1 is an important regulator for both cytokine and TLR-induced responses.

SOCS1, a member of SOCS family, is strongly induced upon TLR stimulation. Cells lacking SOCS1 are hyperresponsive to TLR stimulation. Thus, SOCS1 is an important regulator for both cytokine and TLR-induced responses.

Jun 4, 2019 · In the approach, TLR4-adjuvant monophosphoryl lipid A (MPLA)-stimulated monocyte-activation is reinforced and sustained by silencing SOCS1 via lipid nanoparticle-enclosed siRNA (L-siRNA). L-siRNA is transported into primary cells without any toxic side effects and protected from early degradation.

SOCS1 regulates TLR signaling. TLR4 and TLR7 are pattern recognition receptors known to be responsive toward LPS and ssRNA, respectively. TLR4 and TLR7 signal through NF-kB and IRF7, respectively to induce the expression of target genes.