Mechanistic investigations revealed that SND1 functions as a transcriptional co-activator of hypoxia-inducible factor 1 subunit alpha (HIF1α), thereby regulating the downstream target gene EZH2 and promoting tumorigenesis.

In the present study, we demonstrate that in tumor cells, SND1 is a novel endoplasmic reticulum (ER)–associated protein “hijacking” the nascent heavy chain (HC) of MHC-I to ER-associated degradation (ERAD) process.

The relationship between miR-361-5p and SND1 expression was analyzed in 120 human gliomas and 8 glioma cell lines by in situ hybridization, immunohistochemistry, and Western blot. Dual-luciferase reporter assay was used to identify SND1 as a target of miR-361-5p.

SND1 increases AT1R mRNA stability, causing an increase in AT1R levels resulting in activation of ERK and TGFβ signaling pathway, promoting EMT and migration and invasion by human HCC cells. SND1 mediates endonucleolytic decay of tumor suppressor miRNAs in HEK293T cells promoting upregulation of oncogenic proteins.

Nov 16, 2023 · In mice, prostate-specific Snd1 deletion reduces cancer growth and tumor burden in a prostate cancer model (PB-Cre/Ptenflox/flox / ERG mice), Moreover, we find a significant overlap between...

The MTDH-SND1 interface characterized in this study provides key insights into the molecular basis of their interaction. The essential SND1-binding motif was previously mapped to two different regions of MTDH, residues 364–470 (Blanco et al., …

May 29, 2020 · The amino-terminal peptide of SND1 predominantly associates with SEC61A, which anchors on ER membrane. The SN domain of SND1 catches and guides the nascent synthesized heavy chain (HC) of MHC-I to ER-associated degradation (ERAD), hindering the normal assembly of MHC-I in the ER lumen.

Mar 6, 2017 · In this study, we discovered that SND1 was upregulated in breast cancer tissues, particularly the tissues from patients with distant metastases. The underlying molecular mechanisms demonstrated a...

Staphylococcal nuclease domain-containing protein 1 also known as 100 kDa coactivator or Tudor domain-containing protein 11 (TDRD11) is a protein that in humans is encoded by the SND1 gene. [5] [6] [7] [8] SND1 is a main component of RISC complex [9] and plays an important role in miRNA function.

May 29, 2020 · Oncoprotein SND1 induces ER-associated degradation for nascent MHC-I heavy chain, leading to impaired CD8 + T cell response in tumor. SND1 is highly expressed in various cancers. Here, we identify oncoprotein SND1 as a previously unidentified endoplasmic reticulum (ER) membrane–associated protein.