During membrane fusion, v-SNARE and t-SNARE proteins on separate membranes combine to form a trans-SNARE complex, also known as a "SNAREpin". Depending on the stage of fusion …

Oct 17, 2023 · According to the first model, the R-SNARE binds to a metastable SM–CATCHR–Qa-SNARE acceptor complex (Fig. 3, top panel), thereby connecting the …

The SNARE core complex is a three-molecule, extremely stable four-helix complex, also termed the “SNAREpin” (Li et al., 2007; Sutton et al., 1998; Weber et al., 1998), that bridges the …

Apr 23, 2018 · For efficient disassembly of the SNARE complex, SNAPs and NSF sequentially bind to the complex to form a supercomplex called the 20S complex. With recent advances in …

Aug 16, 2006 · References 39 and 40 show that neuronal SNAREs are aligned in parallel in the SNARE complex, which led to the proposal of the 'zippering' hypothesis of SNARE function.

The interaction between SNARE motifs results in a four-helix coiled-coil structure called the SNARE complex (Sutton et al., 1998), which plays a central role in synaptic vesicle docking, …

Feb 1, 2001 · Provided the first high-resolution crystal structure of a SNARE complex, which was instrumental in elucidating the function of SNARE proteins.

Apr 10, 2019 · The SNARE (soluble N-ethylmaleimide–sensitive factor attachment protein receptor) complex, composed of v-SNARE on the membrane of a vesicle and t-SNARE on the …

Apr 23, 2018 · Here, we introduce the SNARE proteins, their structures and functions in eukaryotic cells, and discuss recent breakthroughs in elucidating the regulation of SNARE …

Mar 11, 2025 · The SNARE complex, composed of three or four SNARE proteins, is highly conserved across species. The core is formed by helices that zipper together from the N …