Glucose transporter 1 (or GLUT1), also known as solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), is a uniporter protein that in humans is encoded by the SLC2A1 gene. [5] GLUT1 facilitates the transport of glucose across the plasma membranes of …

Mar 30, 2025 · SLC2A1 (Solute Carrier Family 2 Member 1) is a Protein Coding gene. Diseases associated with SLC2A1 include Glut1 Deficiency Syndrome 2 and Dystonia 9. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and glycolysis (BioCyc).

GLUT1 deficiency is a rare genetic disorder. It is caused by variants in the SLC2A1 gene. SLC2A1 provides instructions for producing GLUT1. In the brain, the GLUT1 protein is involved in moving glucose from the bloodstream into the cerebrospinal fluid (CSF), which surrounds the brain. Glucose is the brain's main energy source.

The SLC2A1 gene provides instructions for producing a protein called the glucose transporter protein type 1 (GLUT1). The GLUT1 protein is embedded in the outer membrane surrounding cells, where it transports a simple sugar called glucose into …

GLUT1, encoded by the SLC2A1 gene, was one of the first membrane transporters to be purified (Baldwin and Lienhard, 1989; Kasahara and Hinkle, 1977) and cloned (Birnbaum et al., 1986; Mueckler et al., 1985) and is likely one of the most extensively studied of …

A de novo 5'-UTR variant in SLC2A1, generating a novel translation initiation codon, severely compromising SLC2A1 function was identified in a GLUT1 deficiency syndrome patient. High GLUT1 expression is associated with metastasis and epithelial-mesenchymal transition in hepatocellular carcinoma.

Apr 8, 2025 · miR-455-3p ameliorates pancreatic acinar cell injury by targeting Slc2a1. Systemic Reduction of Glut1 Normalizes Retinal Dysfunction, Inflammation, and Oxidative Stress in the Retina of Spontaneous Type 2 Diabetic Mice.

The SLC2A1 gene encodes the major glucose transporter in brain, placenta, and erythrocytes (Baroni et al., 1992). SLC2A1 also transports dehydroascorbic acid (the oxidized form of vitamin C) (Agus et al., 1997) and functions as a receptor for …

Mar 24, 2016 · Multicenter cohort association study of SLC2A1 single nucleotide polymorphisms and age-related macular degeneration.

Apr 5, 2017 · Using whole-genome sequencing, we identified a de novo 5′-UTR variant in SLC2A1, generating a novel translation initiation codon, severely compromising SLC2A1 function.