SkBr3 (also known as SK-BR-3) is a human breast cancer cell line isolated by the Memorial Sloan–Kettering Cancer Center in 1970 that is used in therapeutic research, especially in context of HER2 targeting.

SK-BR-3 [SKBR3] cells were isolated in 1970 from pleural effusion cells of a 43-year-old, White, female adenocarcinoma patient with blood type A+ who had been treated with radiation, steroids, cytoxan, and 5-fluorouracil. Use these cells in your breast cancer research.

Mar 18, 2025 · SKBR3 cells have played a significant role in breast cancer research, particularly in understanding HER2-positive tumors. As a widely studied human breast cancer cell line, SKBR3 has contributed to advancements in targeted therapies and biomarker discovery.

The metastatic SKBR3 cell-membrane proteome revealed a broad and rich map of receptors, immune response, adhesion and transporter proteins that sustain cancer-cell interactions with the native or drug-altered tumor microenvironment.

Initially, well-established breast cancer cell lines, namely SKBR3 and BT474 [9], were used to mimic the in vitro conditions representative of HER2-positive breast cancer. Optimal trastuzumab treatment doses were determined for each cell line based on their respective proliferation rates in response to a wide range of medication dosages.

Part of: ICBP43 breast cancer cell line panel. Part of: KuDOS 95 cell line panel. Part of: MD Anderson Cell Lines Project. From: Memorial Sloan Kettering Cancer Center; New York; USA. Registration: Memorial Sloan Kettering Cancer Center Office of Technology Development; SK 808. Population: Caucasian.

SK-BR-3 is a human breast cancer cell line that overexpresses the Her2 (Neu/ErbB-2) gene product. These cells display an epithelial morphology in tissue culture and are capable of forming poorly differentiated tumors in immunocompromised mice. The SK-BR-3 cells and products derived from it are used often as positive controls in assays for Her2.

Jun 27, 2022 · Our work was aimed at exploring the cell-membrane proteome of a HER2+ breast-cancer cell line (SKBR3) to identify triggers responsible for uncontrolled cell proliferation and intrinsic resources that enable detection and therapeutic interventions.

Cell-membrane cellular subfractions of SKBR3/HER2+ breast cancer cells, used as a model system, were analyzed by high resolution mass spectrometry, and high-quality proteins (FDR<3%) identified by at least two unique peptides were …

Nov 18, 2021 · Through genomic profiling of 733 HER2-amplified breast cancers, we identify enrichment of somatic alterations that promote MEK/ERK signaling in metastatic tumors with shortened progression-free...