- Sirt6, a member of the class III histone deacetylases (HDACs), functions in the regulation of genomic stability, DNA repair, cancer, metabolism and aging. Sirt6 deficiency is lethal, and newborn SIRT6-null cynomolgus monkeys show unfinished brain development.www.sciencedirect.com/science/article/pii/S2589004223027839
SIRT6 is a key regulator of mitochondrial function in the brain
Jan 18, 2023 · Our analysis reveals that SIRT6 is a central regulator of mitochondrial activity in the brain. SIRT6 deficiency in the brain leads to mitochondrial deficiency with a global downregulation of...
Emerging Roles of SIRT6 in Human Diseases and Its …
The biological functions of SIRT6 (e.g. deacetylation, defatty-acylation and mono-ADP-ribosylation) play a pivotal role in regulating lifespan and several fundamental processes controlling aging such as DNA repair, gene …
Sirt6 regulates the proliferation of neural precursor …
Feb 16, 2024 · Combined with the RNA-seq results, the SIRT6 protein may regulate the Notch pathway to influence stem cell proliferation. Our study sheds new light on Sirt6’s crucial role in brain development. Results
A Proteomic Perspective of Sirtuin 6 (SIRT6) Phosphorylation and ...
Sirtuin 6 (SIRT6), a member of the mammalian sirtuin family, is a nuclear deacetylase with substrate-specific NAD + -dependent activity. SIRT6 has emerged as a critical regulator of …
Emerging Therapeutic Potential of SIRT6 Modulators - PMC
Sirtuin 6 (SIRT6) is an NAD+-dependent protein deacylase and mono-ADP-ribosyltransferase of the sirtuin family with a wide substrate specificity. In vitro and in vivo studies have indicated …
Circ-Sirt6 promotes the stability and expression of m6A modified …
Feb 28, 2025 · Mechanistically, circ-Sirt6 specifically binds to IGF2BP2 and promotes the stability and expression of Sirt6 mRNA by enhancing its m 6 A modification. Our findings highlight the …
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Retrotransposon: an insight into neurological disorders from ...
Mar 25, 2025 · SIRT6, a deacetylase involved in the regulation of genomic stability, has been shown to suppress L1 activity in the mouse brain ... RNA-sequencing data of the prefrontal …
Sirtuin 6 is required for the integrated stress response …
May 3, 2023 · Sirtuin 6 (SIRT6) is a NAD + (nicotinamide adenine dinucleotide)–dependent histone deacetylase that acts as a repressor of MYC-driven transcription and has been implicated in cellular stress resistance, …
Restoration of energy homeostasis by SIRT6 extends healthy …
May 28, 2021 · Here, we show that SIRT6 overexpression leads to a reduction in frailty and lifespan extension in both male and female B6 mice. A combination of physiological assays, in …
SIRT6 stabilization and cytoplasmic localization in …
SIRT6 has been shown to positively regulate tumor necrosis factor alpha (TNFα) secretion by demyristoylating pro-TNFα in the cytoplasm. However, how SIRT6, a nuclear chromatin-binding protein, fulfills this function in the cytoplasm is …
