Sirtuin 6 (SIRT6 or Sirt6) is a stress responsive protein deacetylase and mono-ADP ribosyltransferase enzyme encoded by the SIRT6 gene. [5] [6] [7] In laboratory research, SIRT6 appears to function in multiple molecular pathways related to aging, including DNA repair, telomere maintenance, glycolysis and inflammation. [5]

SIRT6 is a longevity protein that can inhibit the aging of cells, tissues, organs and the body by promoting DNA damage repair (5 – 7), maintaining normal chromosome structure (8 – 10), and regulating energy metabolism (11, 12) and the senescence-associated secretory phenotype (SASP) (13, 14).

Jan 18, 2023 · Our analysis reveals that SIRT6 is a central regulator of mitochondrial activity in the brain. SIRT6 deficiency in the brain leads to mitochondrial deficiency with a global...

SIRT6, a member of the Sirtuin family of NAD + -dependent enzymes, has established roles in chromatin signaling and genome maintenance. Through these functions, SIRT6 protects against aging-associated pathologies including metabolic disease and …

Sirtuin 6 (SIRT6) is a nicotinamide adenine dinucleotide+ (NAD+) dependent enzyme and stress response protein that has sparked the curiosity of many researchers in different branches of the biomedical sciences. A unique member of the known Sirtuin ...

In this review, we describe the multiple roles of SIRT6, a chromatin deacylase with unique and important functions in maintaining cellular homeostasis.

Mar 12, 2008 · Here we show that the human SIRT6 protein is an NAD + -dependent, histone H3 lysine 9 (H3K9) deacetylase that modulates telomeric chromatin. SIRT6 associates specifically with telomeres, and...

Jul 17, 2021 · Sirtuin 6 (SIRT6) extends mammalian lifespan and promotes healthspan. SIRT6 maintains genomic stability through improved efficiency of DNA repair. SIRT6 maintains heterochromatin and silences repetitive genetic elements. Regulation of SIRT6 is a potential strategy for rejuvenation.

Feb 6, 2025 · SIRT6 is a NAD +-dependent histone deacetylase with crucial roles in controlling DNA damage repair, telomere homeostasis, oxidative stress, autophagy, and other cellular processes, and it has long been recognized as a longevity-associated protein. This review details its anti-aging-related mechanisms.

Jan 18, 2023 · Our analysis reveals that SIRT6 is a central regulator of mitochondrial activity in the brain. SIRT6 deficiency in the brain leads to mitochondrial deficiency with a global downregulation of mitochondria-related genes and pronounced changes in metabolite content.