Sirtuin 4, also known as SIRT4, is a mitochondrial protein which in humans is encoded by the SIRT4 gene. [5] [6] SIRT4 is member of the mammalian sirtuin family of proteins, which are homologs to the yeast Sir2 protein. SIRT4 exhibits NAD+-dependent deacetylase activity.

Mar 30, 2025 · SIRT4 (Sirtuin 4) is a Protein Coding gene. Diseases associated with SIRT4 include Renu Syndrome and Hyperinsulinemic Hypoglycemia, Familial, 6. Among its related pathways are Regulation of pyruvate metabolism and NAD metabolism.

Apr 17, 2023 · Ammonia production via glutamate dehydrogenase is inhibited by SIRT4, a sirtuin that displays both amidase and non-amidase activities. The processes underlying the regulation of ammonia removal...

For its capability to inhibit glutamine catabolism and for the modulation of genome stability in cancer cells in response to different DNA-damaging conditions, Sirt4 is proposed as either a mitochondrial tumor suppressor or a tumor-promoting protein in a context-dependent manner.

SIRT4 has been shown to play a crucial role in insulin secretion, fatty acid oxidation, amino acid metabolism, ATP homeostasis, apoptosis, neurodegeneration, and cardiovascular diseases. In addition, recent studies have demonstrated that SIRT4 acts as a tumor suppressor.

SIRT4 inhibits insulin secretion in pancreatic β cells and regulates insulin sensitivity as a deacylase in the pancreas. SIRT4 represses fatty acid oxidation (FAO) in muscle and liver cells differently. SIRT4 has also been identified as a mitochondrial-localized tumor suppressor.

Apr 15, 2020 · For its capability to inhibit glutamine catabolism and for the modulation of genome stability in cancer cells in response to different DNA-damaging conditions, Sirt4 is proposed as either a mitochondrial tumor suppressor or a tumor-promoting protein in a …

Feb 8, 2025 · SIRT4 is the molecular switch mediating cellular proliferation in colorectal cancer through GLS mediated activation of AKT/GSK3beta/CyclinD1 pathway. Loss of SIRT4 promotes the self-renewal of Breast Cancer Stem Cells. SIRT4 prevents excitotoxicity via modulating glutamate metabolism in glioma cells.

Mar 16, 2022 · Sirt3 and Sirt4 activate and inhibit glutaminolysis, respectively, by regulating GDH activity. Sirt6 impacts the glutaminolysis pathway by regulating c-Myc transcriptional activity.

NAD+-dependent SIRT4 has been reported to be a key regulator of metabolic enzymes and antioxidant defense mechanisms in mitochondria. It also plays an important role in regulation of mitochondrial metabolism in response to exercise. Recent studies ...