In characterizing the biochemical activity of SirT3, we show that both the full-length and processed forms of SirT3 have a strong NAD + -dependent histone deacetylation activity in vitro with …

Dec 3, 2018 · In this study, we examined the effects of brain mitochondrial protein hyperacetylation in western diet-fed Sirt3 −/− mice, a model for metabolic syndrome. Brain …

SIRT3 is a soluble protein located in the mitochondrial matrix, and contains a mitochondrial processing peptide at the N-terminus.

SIRT3 is a NAD+-dependent deacetylase that regulates the function of numerous mitochondrial proteins with roles in metabolism, oxidative stress, and cell survival. It is emerging as an …

Mar 4, 2010 · Mice lacking SIRT3 exhibit hallmarks of fatty-acid oxidation disorders during fasting, including reduced ATP levels and intolerance to cold exposure.

Aug 18, 2008 · We found that SIRT3 is a stress-responsive deacetylase and that its increased expression protects myocytes from genotoxic and oxidative stress-mediated cell death. We …

Sep 13, 2021 · Sirt3 knockout mice were susceptible to hyper-acetylated mitochondrial proteins and to severe renal fibrosis. The activation of SIRT3 by honokiol ameliorated acetylation and …

Oct 10, 2011 · Here, we show decreased SIRT3 expression, reduced SIRT3 activity, or complete ablation of SIRT3 induces mitochondrial protein hyperacetylation and accelerates the …

Mar 1, 2025 · Inhibits neuroinflammation: SIRT3 suppresses pro-inflammatory microglia and lowers inflammatory cytokines. Protects mitochondria: SIRT3 improves mitochondrial function, …

May 7, 2021 · Here we found that SIRT3 expression was downregulated in senescent human mesenchymal stem cells (hMSCs). CRISPR/Cas9-mediated depletion of SIRT3 led to …