027975 - SIRT3 knock-out Strain Details - The Jackson Laboratory
027975 B6.129S6(Cg)- Sirt3 tm1.1Fwa /J The SIRT3 knock-out allele abolishes sirtuin 3 expression. These mice may be useful in studying the role of fatty acid oxidation in diabetes, …
SIRT3 Blocks Aging-Associated Tissue Fibrosis in Mice by …
Mar 1, 2016 · In this study, we showed a new role for SIRT3 in retarding aging-associated tissue fibrosis. Sirt3-KO mice developed increased blood pressure and had exacerbated tissue …
SIRT3 promotes auditory function in young adult FVB/nJ mice but …
SIRT3 immunoreactivity was significantly greater than that of age-matched, exposure-matched preparations from homozygous Sirt3-KO mice (Fig 1b, red), demonstrating antibody specificity. …
Emerging Roles of SIRT3 in Cardiac Metabolism - PMC
Whole-body SIRT3-KO mice show signs of cardiac hypertrophy and interstitial fibrosis by 8 weeks and exhibit a 19% reduction in lifespan (38, 57). Although these mice appear normal under …
SIRT3 Is Crucial for Maintaining Skeletal Muscle Insulin Action and ...
May 6, 2015 · Permeabilized muscle fibers from HFD-fed SIRT3 knockout (KO) mice showed that tricarboxylic acid cycle substrate–based respiration is decreased while fatty acid–based …
Sirtuin 3 (SIRT3) Pathways in Age-Related Cardiovascular and ...
SIRT3 KO mice show higher visceral fibrosis with aging and increased blood pressure compared to wild-type controls. In addition, SIRT3 deficiency induces human cardiac fibroblast-to …
Mitochondrial Sirtuin Network Reveals Dynamic SIRT3 …
Nov 3, 2016 · In healthy mitochondria, a pool of SIRT3 binds ATP synthase, but upon matrix pH reduction with concomitant loss of mitochondrial membrane potential, SIRT3 dissociates. This …
Sirt3 Deficiency Shortens Life Span and Impairs Cardiac …
In this study, using Sirt3 knockout (Sirt3-/-) mice, we sought to establish whether Sirt3 deficiency affected life span, an endpoint that has never been tested formally in mammals, and uncover …
SIRT3 Blocks Aging-Associated Tissue Fibrosis in Mice by ... - PubMed
Dec 14, 2015 · We found that Sirt3 knockout (KO) mice with age develop tissue fibrosis of multiple organs, including heart, liver, kidney, and lungs but not whole-body SIRT3 …
Decreased Neuron Number and Synaptic Plasticity in SIRT3-Knockout Mice ...
Interestingly, SIRT1, another member of the sirtuin family, has been reported to modulate synaptic plasticity and memory formation. To learn more about these proteins, we examined the …