SIRT2 gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped …

This review summarizes the functions of SIRT2 in the nervous system, mitosis regulation, genome integrity, cell differentiation, cell homeostasis, aging, infection, inflammation, oxidative stress, …

Mar 30, 2025 · SIRT2 (Sirtuin 2) is a Protein Coding gene. Diseases associated with SIRT2 include Primary Hyperoxaluria and Thrombocytopenia. Among its related pathways are Cell …

Sirtuin 2 (SIRT2), as a member of the sirtuin family, has representative features of evolutionarily highly conserved nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase activity.

Concerning SIRT2, a recent study has found that SIRT2 KO mice present improved neurological function and spatial memory together with fewer protein levels of NLRP3, ASC, caspase-1, IL …

May 24, 2021 · As a type of nicotinamide adenine dinucleotide (NAD +)-dependent deacetylases, sirtuin 2 (SIRT2) is predominantly found in the cytoplasm of cells in the central nervous system …

Aug 1, 2023 · The deacetylase SIRT2 is a response to ageing that delays vascular ageing, and the cytoplasm-mitochondria axis (SIRT2-p66Shc-mROS) is important for vascular ageing. …

Silent information regulator 2 (Sirtuin2 / SIRT2) is a NAD + -dependent deacetylase that regulates the cellular oxidative stress response. It modulates transcriptional silencing and protein …

2 days ago · A research team has identified a previously unknown enzyme, SIRT2, that plays a key role in memory loss associated with Alzheimer's disease (AD). The study provides critical …

Nov 1, 2019 · Sirtuin 2 (SIRT2) is an NAD+-dependent deacetylase that was under studied compared to other sirtuin family members. SIRT2 is the only sirtuin protein which is …