Dec 1, 2000 · SHP-2, a cytoplasmic SH2 domain containing protein tyrosine phosphatase, is involved in the signaling pathways of a variety of growth factors and cytokines.

The role of SHP-2 in T cells is even less understood due to numerous contradicting reports. It is most likely that SHP-2 has different functions in T cells depending on the environment and signaling pathways involved, and also the developmental stage of the T cells.

Nov 8, 2021 · Illustration of potential signaling pathways controlled by Src homology 2 (SH2) domain-containing protein tyrosine phosphatase 2 (SHP-2). Similar to SHP-1, SHP-2 has a critical role in a host of cellular signal transduction pathways that involve cell proliferation, differentiation, survival, and apoptosis.

Sep 6, 2022 · As reported by Martin and Agazie, SHP2 stabilizes and sustains cytoplasmic and nuclear pools of β-catenin in TNBC cells independent of Wnt signaling. Mechanistically, SHP2 mediates GSK3β inactivation through AKT and ERK1/2 pathways to …

Feb 11, 2025 · SHP-2 acts as a molecular switch, toggling pathways in response to stimuli. SHP-2 also impacts the JAK/STAT pathway, crucial for processes like hematopoiesis and immune responses, by dephosphorylating JAK kinases.

Dec 29, 2022 · The inhibitory receptor PD-1 suppresses T cell activation by recruiting the phosphatase SHP-2. However, mice with a T-cell-specific deletion of SHP-2 do not have improved antitumor immunity.

We propose that Shp-2 acts to promote cell growth and survival through two mechanisms, i.e., the stimulation of growth factor-initiated mitogenic pathways and the suppression of cytotoxic effect elicited by cytokines, such as IFNs.

Shp2 is a ubiquitous tyrosine phosphatase containing Src Homology 2 domains which plays major biological functions in response to various growth factors, hormones or cytokines. This is essentially due to its particularity of promoting the activation of the Ras/Mitogen-activated protein kinase pathwa …

Oct 25, 2019 · Here, we discuss recent advances in the understanding of how SHP-2 shapes these pathways and highlight open questions that—with the advent of inhibitors for clinical use—are becoming increasingly pressing. SHP-2 possesses two N-terminal SH2 domains (N-SH2 and C-SH2) and a central protein tyrosine phosphatase (PTP) core (Figure 1) (3, 4, 27 – 30).

SHP2 recruited by PD-1 receptor can exert immunosuppressive effects through the following signal pathways: ① direct inhibition of downstream PI3K-AKT signaling pathway; ② dephosphorylation of ZAP70 to indirectly inhibit PI3K-AKT and RAS-ERK pathways; ③ dephosphorylation of T cell-activated co-receptor CD28 to indirectly inhibit PI3K-AKT ...