The below discussed examples of inhibitory receptors are thought to mediate their inhibitory function at least partially through SHP-1 and/or SHP-2. In addition to these reviewed examples, a number of additional inhibitory receptors have been found in a complex with SHP-1 and/or SHP-2.

Dec 1, 2000 · SHP-2, a cytoplasmic SH2 domain containing protein tyrosine phosphatase, is involved in the signaling pathways of a variety of growth factors and cytokines.

Jun 13, 2011 · Using cultured normal human fibroblasts, immunoprecipitation and western blots, we show for the first time that SHP-2 and PLCβ1 are present as a preformed complex.

May 5, 1998 · Src homology 2 (SH2) domain–containing phosphotyrosine phosphatases (SHPs) are increasingly being shown to play critical roles in protein tyrosine kinase–mediated signaling pathways. The role of SHP-1 as a negative regulator of …

SHP-2 is an SH2 domain-containing tyrosine phosphatase, which positively regulates growth and differentiation. We show that in C2C12 myoblasts, SHP-2 becomes upregulated early on during myogenesis and associates with a 120 kDa tyrosyl-phosphorylated complex.

Feb 20, 1998 · SHP-2 is expressed in every tissue and transmits signals in cells that are activated by various ligands, including growth factors, cytokines, hormones, and MHC-antigen complexes. SHP-1 expression is limited primarily to hematopoietic and epithelial cells.

We propose that SHP-2 plays a pivotal role in FGFR signaling in myoblasts via both Erk-dependent and Erk-independent pathways. Cell lines of the myogenic lineage provide an excellent model for studying signaling pathways that …

May 1, 1998 · SHP-2 is an ubiquitously expressed cytosolic protein tyrosine phosphatase composed of two amino-terminal SH2 domains, a central phosphatase domain and a carboxy-terminal tail.

Feb 25, 1999 · The protein tyrosine phosphatase SHP-2 functions in many diverse signalling pathways. The recent identification of a SHP-2-binding protein as a homologue of the Grb2-associated adaptor protein Gab1 sheds light on the role of SHP-2 in immune signalling.

Oct 25, 2019 · The phosphotyrosine phosphatase SHP-2 participates in a multimeric signaling complex and regulates T cell receptor (TCR) coupling to the Ras/mitogen-activated protein kinase (MAPK) pathway in Jurkat T cells.