Src homology 2 (SH2) domain containing protein tyrosine phosphatase …
Mar 31, 2008 · Vascular endothelial growth factor receptor-2 (VEGFR-2, KDR), a receptor tyrosine kinase, regulates mitogenic, chemotactic, hyperpermeability, and survival signals in …
Deletion of AT2 Receptor Prevents SHP-1–Induced VEGF …
Oct 26, 2017 · Our results suggest that the deletion of AT2 receptor reduced SHP-1 activity and restored VEGF actions, leading to an increased blood flow reperfusion after ischemia in …
Endothelial SHP-1 regulates diabetes-induced abnormal collateral …
We showed that hyperglycemia induced expression of the protein tyrosine phosphatase SHP-1, which reduced angiogenic factor activity in ischemic muscle of diabetic mice. Here, we …
Disrupting VEGF-A paracrine and autocrine loops by targeting SHP …
Jul 1, 2016 · We found a significant correlation between cancer cell migration and SHP-1/p-STAT3/VEGF-A expression in human TNBC cells. Clinically, high VEGF-A expression is …
Src homology 2 (SH2) domain containing protein tyrosine ... - PubMed
Mar 31, 2008 · Taken together our results define the tyrosine residues of KDR that are regulated by SHP-1 and also elucidates a novel feed back loop where SHP-1 is activated upon VEGF …
The Tyrosine Phosphatase SHP-1 Regulates Hypoxia Inducible
Mar 23, 2015 · SHP-1 knock-down by specific antisense oligodesoxynucleotides (AS-Odn) increased cell growth as well as VEGF synthesis and secretion during 24 hours of hypoxia …
Glomerular VEGF resistance induced by PKCδ/SHP-1 activation …
This study characterizes the effect of glucose-induced activation of protein kinase Cδ (PKCδ) and Src homology-2 domain-containing phosphatase-1 (SHP-1) expression on vascular endothelial …
SHP-1 knock-down increased cell growth and VEGF
Introduction: The tyrosine phosphatase SHP-1 negatively influences endothelial function, such as VEGF signaling and reactive oxygen species (ROS) formation, and has been shown to …
Src homology 2 (SH2) domain containing protein tyrosine …
Mar 31, 2008 · Vascular endothelial growth factor receptor-2 (VEGFR-2, KDR), a receptor tyrosine kinase, regulates mitogenic, chemotactic, hyperpermeability, and survival signals in …
SiRNA targeting SHP-1 accelerates angiogenesis in a rat model of ...
Nov 12, 2005 · Vascular endothelial growth factor (VEGF) receptor-2 (KDR/flk-1) has a tyrosine kinase domain, and once activated, induces the autophosphorylation of the tyrosine residues, …
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