SHC-transforming protein 1 is a protein that in humans is encoded by the SHC1 gene. [5] . SHC has been found to be important in the regulation of apoptosis and drug resistance in mammalian cells. SCOP classifies the 3D structure as belonging to the SH2 domain family.

Mar 30, 2025 · SHC1 (SHC Adaptor Protein 1) is a Protein Coding gene. Diseases associated with SHC1 include Breast Cancer and Multiple Endocrine Neoplasia, Type Iia. Among its related pathways are IL-9 Signaling Pathways and Downstream signaling of activated FGFR2.

p66Shc (SHC1) protein through a redox mechanism enhances the progression of prostate cancer cells towards castration-resistance. In B cell lymphoma cells, reactive oxygen species production promoted p66shc expression, induced DNA damage, and facilitated cell apoptosis.

SHC1 expression was associated with five MMR genes in human pan-cancers, especially in liver cancer. SHC1 expression was also positively correlated with three DNMTs (DNMT1, DNMT3A, and DNMT3B) in human cancers, especially in DLBC, KICH, KIRC, KIRP, LGG, LIHC, LUAD, MESO, TGCT, and UVM.

The Shc family consists of four members encoded by four distinct genes: Shc/Shc1/ShcA, Sli/Shc2/ShcB, Rai/Shc3/ShcC and RaLP/Shc4/ShcD (Figure 1). Broadly, Shc proteins contribute to mediating several intracellular signalling cascades; they are implicated in cell proliferation, cell differentiation, cell survival and migration [ 7 , 8 , 9 ].

Aug 30, 2024 · SHC1 plays a crucial regulatory role in various tumors, but its significance in predicting prognosis and immune response in clear cell renal cell carcinoma (ccRCC) is yet to be determined.

Feb 9, 2025 · Title: MicroRNA 452 regulates SHC1 expression in human colorectal cancer and colitis. YES1 Kinase Mediates the Membrane Removal of Rescued F508del-CFTR in Airway Cells by Promoting MAPK Pathway Activation via SHC1.

Shc1, a prototypical scaffold protein, plays a pivotal role in directing phosphotyrosine (pY)-dependent protein complex formation for numerous RTKs typically through its two pY-binding domains. The three conserved pY sites within its CH1 region (Shc1 CH1) hold particular significance due to their substantial contribution to its functions.

Feb 8, 2025 · Activation of Shc1 Allows Oncostatin M to Induce RANKL and Osteoclast Formation More Effectively Than Leukemia Inhibitory Factor. results highlight p66Shc deficiency as an important factor in the progression and severity of chronic lymphocytic leukemia and underscore p66Shc expression as a relevant therapeutic target.

Jun 15, 2019 · Background: SHC1 proteins (also called SHCA) exist in three functionally distinct isoforms (p46SHC, p52SHC, and p66SHC) that serve as intracellular adaptors for several key signaling pathways in breast cancer.