We present evidence suggesting that SFRP1 functions as a secreted mediator of senescence through inhibition of Wnt signaling and activation of the retinoblastoma (Rb) pathway and that cancer-associated SFRP1 mutants are defective for senescence induction.

Aug 6, 2019 · SFRP1 has a biphasic effect on Wnt signaling. At low concentrations, SFRP1 increases Wnt activity; however, Wnt activity is reduced under high concentrations of SFRP1 (Uren et al., 2000).

Aug 6, 2020 · Secreted frizzled related protein 1 (SFRP1) is one of the extracellular ligands of WNT signalling. We performed bioinformatics analyses of SFRP1 expression in human cancer.

Secreted frizzled-related protein 1 (SFRP1) is a member of the SFRP family that contains a cysteine -rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP1 and SFRP5 may be involved in determining the polarity of photoreceptor cells in the retina.

Dec 14, 2008 · Secreted Frizzled-related proteins (sFRPs) are signalling molecules well-known as antagonists of the Wnt pathway, but recent studies indicate that they may have additional functions...

(A) SFRP1 inhibits Wnt activity by directly binding to the ligand of Wnt protein through its netrin (NTR) domain. ( B ) SFRP1 antagonizes the Wnt signaling pathway by bypassing the interaction with the Wnt ligand and directly binding to the cytoplasmic β-catenin.

Secreted frizzled-related proteins (Sfrps) such as Sfrp1 can function as inhibitors of Wnt signaling. In the present study a potential role of Wnt signaling in denervation was examined by comparing the expression levels of Sfrp1 and key proteins in the canonical Wnt pathway, Dishevelled, glycogen synthase kinase 3beta and beta-catenin, in ...

Apr 5, 2008 · In the present study a potential role of Wnt signaling in denervation was examined by comparing the expression levels of Sfrp1 and key proteins in the canonical Wnt pathway, Dishevelled, glycogen synthase kinase 3β and β-catenin, in innervated and denervated rodent skeletal muscle.

Apr 16, 2024 · Secreted frizzled-related protein 1 (Sfrp1) is an extracellular protein that modulates Wnt signaling. However, the cells that produce Sfrp1 in the tumor environment and its function remain unclear. We aimed to elucidate angiocrine factors related to …

The restoration of sFRP1 expression in cancer cells by ectopic expression inhibited Wnt activity accompanied with destabilization of β-catenin and downregulation of c-Myc and cyclin D1, the known downstream targets of Wnt pathway.