SENP1 (Sentrin-specific protease 1) is a human protease of 643 amino acids with a molecular weight of 73 kDa, EC number in humans 3.4.22.B70. It adopts a conformation that identifies it as a member of the superfamily of cysteine proteases, which contain a catalytic triad with three characterized amino acids: a cysteine at position 603, a ...

Dec 25, 2024 · SENP1 (SUMO Specific Peptidase 1) is a Protein Coding gene. Diseases associated with SENP1 include Chronic Mountain Sickness and Combat Disorder. Among its related pathways are Signaling by Rho GTPases and Transport of …

Nov 22, 2022 · Here we identified SENP1, a SUMO-specific protease, as a key endogenous inhibitor of RIPK1. SENP1 is progressively reduced in proportion to NASH severity in patients. Hepatocyte-specific...

Sentrin‐specific protease 1 (SENP1) is a protease that is important for tumor development and drug resistance. 1 , 2 Our recent discovery indicates that SENP1 is critical for Janus kinase/signal transducers and activators of transcription (JAK2/STAT) signaling by regulating JAK2 activity through deSUMOylation. 1 Therefore, targeting SENP1 is ...

Jan 5, 2025 · SENP1 restored the promyelocytic leukemia protein mediated suppression of STAT3 activation. SENP1 mediates TNF-induced desumoylation and translocation of HIPK1, leading to an enhanced ASK1-dependent apoptosis. SENP1 may act as redox sensors and effectors modulating the desumoylation pathway and …

Apr 1, 2021 · To explore the application of anti-SENP1/JAK2 for treatment of platinum-resistant ovarian cancer, we found SENP1 deficiency or treatment by SENP1 inhibitor Momordin Ic significantly overcomes...

Nov 22, 2022 · Here we identified SENP1, a SUMO-specific protease, as a key endogenous inhibitor of RIPK1. SENP1 is progressively reduced in proportion to NASH severity in patients. Hepatocyte-specific SENP1-knockout mice develop spontaneous NASH-related phenotypes in a RIPK1 kinase-dependent manner.

Sep 23, 2016 · Senp1−/− primary MEF cells show resistance to cell senescence induced by passaging or other senescence inducing signals. SENP1 deficiency also reduces oncogene H-Ras V12 -induced senescence,...

Silencing SENP1 levels perturbed prostate and pancreas cancer cells’ ability to metastasize through the down-regulation of matrix metalloproteinase 9 (MMP9). Additionally to MMP9, SENP1 regulated the expression of MMP2 through the HIF-1α signaling pathway in prostate cancer [11].

Aug 22, 2019 · SENP1 deficiency results in hyper-SUMOylation of Sirt3 and hyper-acetylation of mitochondrial proteins, which reduces mitochondrial metabolic adaption responding to fasting. Furthermore, we find that fasting induces SENP1 translocation into mitochondria to activate Sirt3.