Laser fluorescence changes demonstrated superior results for P11-4 with fluoride and SAP P11-4 with SAPM as compared to control (only fluoride). ICDAS-II codes and Nyvad Caries Activity at day 360 also showed superior caries inactivation

Apr 11, 2023 · Real-world clinical data indicate that SAP P 11 -4 can lead to recovery and a healthier tooth stage. SAP P 11 -4 is a safe treatment for initial caries lesions in permanent teeth that remineralizes in the deepest zone of the lesion …

Nov 19, 2020 · Recent randomized gold-standard controlled clinical trials have shown SAP P 11 -4 combined with fluoride varnish or a Self-Assembling Peptide Matrix Gel to be superior for the treatment of...

May 26, 2023 · Simple noninvasive evidence-based interventions for caries are needed to overcome limitations in the restorative paradigm. The self-assembling peptide P 11 -4 is a noninvasive intervention that regenerates enamel in initial caries lesions.

Nov 19, 2020 · SAP P 11-4 treatment resulted in superior caries regression compared to either placebo or FV, and FV efficacy seems not to be affected by SAP P 11-4. SAP P 11 -4 was found to be a safe and effective WSL treatment.

Nov 5, 2020 · One of the materials used for enamel regeneration is self-assembling peptide P 11 -4. When it is applied to the carious lesion, the peptide undergoes one-dimensional self-assembly, including formation of nanotapes, ribbons, fibrils and fibers.

In five studies that evaluated the relative efficacy of SAP P 11-4 with CPP-ACP, the SAP P 11-4 was found to have a superior remineralization potential compared to CPP-ACP in artificially induced early enamel lesions. 1, 6, 7, 18, 20

Objective: The present systematic review was conducted to investigate the effect of the self-assembling peptide (SAP) - P 11-4 in the remineralization of enamel caries. Material and methods: The systematic search for studies was conducted through CINAHL, EMBASE, MEDLINE, Scopus, PsychINFO, and various key journals.

Mar 6, 2020 · Non-invasive caries treatment is a major focus in modern dentistry. The present study was designed to evaluate the effectiveness of monomeric self-assembling peptide P 11 -4 (SAP P 11 -4)...

May 5, 2022 · This review presents a narrative overview of the application of self-assembling peptide P 11-4 (SAP P 11 - 4) in therapeutics and hard tissue engineering, including enamel regeneration via self-assembly of organized nanostructures.