S100 calcium-binding protein A8 (S100A8) is a protein that in humans is encoded by the S100A8 gene. [5] It is also known as calgranulin A. The proteins S100A8 and S100A9 form a heterodimer called calprotectin .

Mar 30, 2025 · S100A8 (S100 Calcium Binding Protein A8) is a Protein Coding gene. Diseases associated with S100A8 include Peptic Ulcer Disease and Duodenal Ulcer. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Diseases of Immune System.

S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions.

Aug 6, 2018 · Calprotectin (S100A8/S100A9), a heterodimeric EF-hand Ca2+ binding protein, are abundant in cytosol of neutrophils and are involved in inflammatory processes and several cancerous pathogens. The purpose of the present systematic review is to evaluate the pro- and anti-tumorigenic functions of calprotectin and its relation to inflammation.

Jun 11, 2018 · In this review, we provide a comprehensive and detailed overview of the distribution and biological functions of S100A8/A9 and highlight its application as a diagnostic and therapeutic target in inflammation-associated diseases. Inflammation is a basic defense mechanism in the human body.

Dec 19, 2024 · Cytosolic S100A8/A9 enhances Ca2+ availability at LFA-1 adhesion sites, facilitating neutrophil recruitment and extravasation by supporting proper integrin signaling and cytoskeletal rearrangement.

Aug 28, 2023 · S100A8/A9, a heterodimer protein mainly generated by neutrophils, triggers many signal transduction pathways to mediate microtubule constitution and pathogen defense, as well as intricate procedures of cancer growth, metastasis, drug resistance, and prognosis.

Mar 15, 2003 · Recombinant proteins were generated and their proinflammatory properties toward neutrophils were characterized in vitro. S100A8, S100A9, and S100A8/A9 proved to be chemotactic for neutrophils in vitro and also stimulated shedding of L-selectin and up-regulation and activation of Mac-1.

Helicobacter pylori infection is associated with the development of a chronic inflammatory response, which may induce peptic ulcers, gastric cancer (GC), and mucosa-associated lymphoid tissue (MALT) lymphoma.

S100A8/A9 upregulated Acod1 and p-JAK2 to induce the activation of STAT3 signaling, resulting in an increased transcription of Il23a, which promoted Th17 cell response and the development of SjDED.