S100A7 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation.S100 genes include at least 13 members which are located as a cluster on chromosome 1q21.

Mar 30, 2025 · S100A7 (S100 Calcium Binding Protein A7) is a Protein Coding gene. Diseases associated with S100A7 include Bladder Squamous Cell Carcinoma and Psoriasis. Among its related pathways are Innate Immune System and Defensins. Gene Ontology (GO) annotations related to this gene include calcium ion binding and RAGE receptor binding.

Aug 21, 2017 · Considering the relevance of S100A7 in cancer progression, we have developed neutralizing monoclonal antibodies, reporting for the first time the proof of principle of this promising therapeutic...

Dysregulated expression of S100A7 is found in several cancers and plays an important role in tumor progression; however, its carcinogenic role in esophageal squamous carcinoma (ESCC) is still poorly understood. Here, we identified that the levels of ...

S100A7, S100A8/A9, S100A12, and S100A15, well-documented DAMPs, have been shown to participate inflammatory tissue damage and tissue repair. The link between S100A12 and the severity of coronary and carotid atherosclerosis has been evidenced by …

S100A7 expression appears to stabilize epidermal fatty acid binding protein level in keratinocytes; Increased Psoriasin expression is associated with acne pathogenesis. S100A7 was identified and validated as being associated with lung squamous cell carcinoma metastasis to the brain.

Dec 7, 2017 · This work aims to deepen in the role played by extracellular S100A7 in the tumor microenvironment, offering a new integrative insight of its mechanism of action on each cellular compartment (tumor, endothelial, immune and fibroblast).

Oct 21, 2022 · In our previous studies, we have demonstrated that psoriasin, also known as S100 calcium-binding protein A7 (S100A7), not only accelerates tumor progression via the activation of the p-Erk...

Feb 4, 2024 · Title: S100A7 Co-localization and Up-regulation of Filaggrin in Human Sinonasal Epithelial Cells. S100A7 as a potential diagnostic and prognostic biomarker of esophageal squamous cell carcinoma promotes M2 macrophage infiltration and angiogenesis.

The antimicrobial S100 protein (S100A7, also known as psoriasin) was found to be highly expressed in inflamed psoriatic skin or, more commonly, in healthy skin. S100A7 also acts as a chemotactic factor for immune cells, stimulating cell proliferation or differentiation, triggering cytokine/chemokine synthesis (immunomodulatory), and enhancing ...