Ryanodine receptor 2 - Wikipedia
Ryanodine receptor 2 (RYR2) is one of a class of ryanodine receptors and a protein found primarily in cardiac muscle. In humans, it is encoded by the RYR2 gene. [5] [6] [7] In the …
RYR2 gene - MedlinePlus
The RYR2 gene provides instructions for making a protein called ryanodine receptor 2. This protein is part of a family of ryanodine receptors, which form channels that transport positively …
RYR2-ryanodinopathies: from calcium overload to calcium …
The sarcoplasmatic reticulum (SR) cardiac ryanodine receptor/calcium release channel RyR2 is an essential regulator of cardiac excitation–contraction coupling and intracellular calcium …
RYR2 Gene - GeneCards | RYR2 Protein | RYR2 Antibody
Mar 30, 2025 · RYR2 (Ryanodine Receptor 2) is a Protein Coding gene. Diseases associated with RYR2 include Ventricular Arrhythmias Due To Cardiac Ryanodine Receptor Calcium Release …
Human RyR2 (Ryanodine Receptor 2) Loss-of-Function Mutations:
Sep 1, 2021 · Gain-of-function mutations in the cardiac Ca 2+ release channel (RyR2 [ryanodine receptor 2]) cause catecholaminergic polymorphic ventricular tachycardia, whereas loss-of …
RyR2 gain-of-function and not so sudden cardiac death - PMC
Gain-of-function of the cardiac ryanodine receptor (RyR2), the major Ca 2+ release channel of the sarcoplasmic reticulum (SR), can be catastrophic, and is associated with sudden cardiac …
Molecular basis for gating of cardiac ryanodine receptor ... - Nature
May 20, 2022 · Cardiac ryanodine receptor (RyR2) is a large Ca 2+ release channel in the sarcoplasmic reticulum and indispensable for excitation-contraction coupling in the heart. …
Molecular, Subcellular, and Arrhythmogenic Mechanisms in Genetic RyR2 …
The ryanodine receptor (RyR2) has a critical role in controlling Ca2+ release from the sarcoplasmic reticulum (SR) throughout the cardiac cycle. RyR2 protein has multiple functional …
6262 - Gene ResultRYR2 ryanodine receptor 2 [ (human)]
RYR2 variants show possible pathogenic Fibrosis of the Cardiac Conduction system. The most common form of CPVT is due to autosomal dominant variants in the cardiac ryanodine …
RYR2 ryanodine receptor 2 [ Homo sapiens (human) ]
Jan 4, 2025 · Common RyR2 variants associate with ventricular arrhythmias and sudden cardiac death in chronic heart failure. Ran Y, et al. Clin Sci (Lond), 2010 Jun 4. PMID 20408814. High …