Jan 6, 2022 · Taken together, our findings reveal a previously unknown mechanism by which hypoxia promotes wound healing by promoting reepithelialization through the production of ROS, inducing keratinocyte EMT and migration via the enhancement of SOX2 and activation of …

Next, we showed that the expression of sex-determining region Y-box 2 (SOX2), a stemness-associated molecule, is ROS-dependent under hypoxia and that SOX2 inhibition in keratinocytes dramatically prevented hypoxia-induced EMT and migration.

Jan 30, 2019 · These results suggest that NOX1/ROS signaling has an important role in increased proliferation of stomach epithelial cells in the inflamed mucosa. Moreover, we found that expression of SOX2, a...

Reactive oxygen species (ROS) is a key mediator in the process of radiotherapy-induced cell damage 20, and the hypoxic state of CSC can reduce the intracellular ROS level and enhance the tolerance of CSC to radiation 21.

Jan 31, 2022 · Superoxide (O 2 ˙ −), hydrogen peroxide (H 2 O 2), and the hydroxyl free radical (HO.) mainly comprise the group called reactive oxygen species or ROS, and are formed due to oxygen atoms capturing electrons.

Dec 3, 2020 · Silencing SOX2‐OT expression inhibited NLRP3, ASC, caspase‐1, IL‐1β, and TGF‐β1 expression and ROS production, reduced the degrees of cardiomyocyte necrosis and fibrosis and alleviated cardiac dysfunction in rats with VA‐HF. MicroR‐2355‐3p can bind the SOX2‐OT and the 3′‐untranslated region of NLRP3.

May 3, 2016 · Zhou et al. show that early generation of reactive oxygen species (ROS) is required for nuclear reprogramming of somatic cells to pluripotency. Genetic knockdown and knockout of the oxidative enzyme Nox (1–4), or addition of antioxidants, suppresses reprogramming.

Our results suggested that cultivation of cancer cells under conditions of serum deprivation in an anchorage-independent manner may enrich SOX-2-expressing CSC-like cells in vitro. More efficient isolation and identification of cancer stem cells (CSCs) would help in determining their fundamental roles in tumor biology.

Jan 6, 2022 · Taken together, our findings reveal a previously unknown mechanism by which hypoxia promotes wound healing by promoting reepithelialization through the production of ROS, inducing keratinocyte...

These key regulatory functions of SOX2 involve complex regulatory networks, including protein-protein and protein-nucleic acid interactions through signaling pathways and noncoding RNA interactions, modulating SOX2 expression may be a potential therapeutic strategy for …