The phosphatidylinositol 3-kinase (PI3K) pathway played an important role in regulating the autophagic response of cells in response to changing reactive oxygen species (ROS) levels.

Jul 24, 2018 · In this study, we provide evidences that mtROS induce PTEN oxidation to stimulate PI3K/AKT/mTOR signaling pathway and thus promote autophagy, which is required for muscle differentiation and...

Oct 24, 2019 · In this study, we showed that chaetocin, a natural product isolated from the Chaetomium species of fungi, inhibited proliferation, induced G 2 /M phase arrest and caspase-dependent apoptosis in...

Dec 3, 2019 · Mechanistically, ROS-induced oxidative stress regulates the opening of connexin channels in a system mediated by phosphoinositide 3-kinase (PI3K) activation, which allows the mitochondria to transfer from BMSCs into HSCs.

Combination treatment of Rhein and oxaliplatin synergistically enhanced apoptosis of PC cells through increased generation of intracellular reactive oxygen species (ROS) and inactivation of the PI3K/AKT pathway.

Phosphoinositide 3-kinases (PI3Ks) are a family of kinases that generate lipid second messengers to recruit cytoplasmic proteins to cellular membrane. The PI3K enzymes can be divided into three classes according to their substrate specificity, structure and function.

Jan 8, 2022 · Upregulation of HIF-1α in 5-FU-resistant CRC occurred through non-oxygen-dependent mechanisms of reactive oxygen species-mediated activation of PI3K/Akt signaling and aberrant activation of β-catenin in the nucleus. Both HIF-1α gene knock-down and pharmacological inhibition restored the sensitivity of CRC to 5-FU.

May 15, 2018 · Aberrant PI3K/Akt signaling drives many of the molecular mechanisms contributing to increased ROS levels through direct modulation of mitochondrial bioenergetics and activation of NADPH oxidases (NOXs), or indirectly through the production of ROS as a metabolic by-product (Figure 1) (6, 18).

Jun 1, 2014 · Schematic representation of PI3K/AKT/PTEN signaling, which modulate NOXs-derived ROS. NOXs sense hypoxia and can help to mediate activation of angiogenic pathway, while maintaining unregulated cell growth and apoptotic cell death.

Jan 8, 2022 · Here, we show that the metabolic reprogramming that facilitates 5-FU resistance in CRC arises from HIF-1α upregulation in non-classical ways, by ROS and the Wnt/β-catenin signaling pathway, independently from external oxygen concentrations.